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Anthony J. Hannan
Researcher at Florey Institute of Neuroscience and Mental Health
Publications - 301
Citations - 14414
Anthony J. Hannan is an academic researcher from Florey Institute of Neuroscience and Mental Health. The author has contributed to research in topics: Huntington's disease & Environmental enrichment. The author has an hindex of 56, co-authored 271 publications receiving 12306 citations. Previous affiliations of Anthony J. Hannan include University of Oxford & Nepean Hospital.
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Journal ArticleDOI
Enriched environments, experience-dependent plasticity and disorders of the nervous system.
TL;DR: Findings on the environmental modulators of pathogenesis and gene–environment interactions in CNS disorders, and their therapeutic implications, are reviewed.
Journal ArticleDOI
Delaying the onset of Huntington's in mice.
TL;DR: It is shown that exposure of these mice to a stimulating, enriched environment from an early age helps to prevent the loss of cerebral volume and delays the onset of motor disorders.
Journal ArticleDOI
Environmental Enrichment Rescues Protein Deficits in a Mouse Model of Huntington's Disease, Indicating a Possible Disease Mechanism
Tara L. Spires,Helen E Grote,Neelash K. Varshney,Patricia M. Cordery,Anton van Dellen,Colin Blakemore,Anthony J. Hannan +6 more
TL;DR: The results suggest that environmental enrichment benefits animals at early stages of the disease by rescuing protein deficits, possibly through rescuing transcription or protein transport problems.
Journal ArticleDOI
Environmental enrichment slows disease progression in R6/2 Huntington's disease mice
Emma Hockly,Patricia M. Cordery,Benjamin Woodman,Amarbirpal Mahal,Anton van Dellen,Colin Blakemore,Cathryn M. Lewis,Anthony J. Hannan,Gillian P. Bates +8 more
TL;DR: It is found that even limited environmental enrichment slows decline in RotaRod performance in R6/2 mice, despite rapid disease progression, whereas in normal littermates, maximal enrichment was required to induce a marked improvement in behavioral tests.
Journal ArticleDOI
Mutant huntingtin's effects on striatal gene expression in mice recapitulate changes observed in human Huntington's disease brain and do not differ with mutant huntingtin length or wild-type huntingtin dosage
Alexandre Kuhn,Darlene R. Goldstein,Angela Hodges,Angela Hodges,Andrew D. Strand,Thierry Sengstag,Charles Kooperberg,Kristina Becanovic,Mahmoud A. Pouladi,Kirupa Sathasivam,Jang Ho J. Cha,Anthony J. Hannan,Michael R. Hayden,Blair R. Leavitt,Stephen B. Dunnett,Robert J. Ferrante,Roger L. Albin,Peggy F. Shelbourne,Mauro Delorenzi,Sarah J. Augood,Richard L.M. Faull,James M. Olson,Gillian P. Bates,Lesley Jones,Ruth Luthi-Carter +24 more
TL;DR: The discovery that several available lines of HD mice faithfully recapitulate the gene expression signature of the human disorder provides a novel aspect of validation with respect to their use in preclinical therapeutic trials.