scispace - formally typeset
Search or ask a question
Author

Anthony J. Mancuso

Bio: Anthony J. Mancuso is an academic researcher. The author has contributed to research in topics: Dimethyl sulfoxide & Oxalyl chloride. The author has an hindex of 3, co-authored 3 publications receiving 2513 citations.


Cited by
More filters
Journal ArticleDOI
TL;DR: The fundamental concepts underlying the principles of green and sustainable chemistry--atom and step economy and the E factor--are presented, within the general context of efficiency in organic synthesis, and the transition from fossil-based chemicals manufacture to a more sustainable biomass-based production is discussed.
Abstract: In this tutorial review, the fundamental concepts underlying the principles of green and sustainable chemistry - atom and step economy and the E factor - are presented, within the general context of efficiency in organic synthesis. The importance of waste minimisation through the widespread application of catalysis in all its forms – homogeneous, heterogeneous, organocatalysis and biocatalysis – is discussed. These general principles are illustrated with simple practical examples, such as alcohol oxidation and carbonylation and the asymmetric reduction of ketones. The latter reaction is exemplified by a three enzyme process for the production of a key intermediate in the synthesis of the cholesterol lowering agent, atorvastatin. The immobilisation of enzymes as cross-linked enzyme aggregates (CLEAs) as a means of optimizing operational performance is presented. The use of immobilised enzymes in catalytic cascade processes is illustrated with a trienzymatic process for the conversion of benzaldehyde to (S)-mandelic acid using a combi-CLEA containing three enzymes. Finally, the transition from fossil-based chemicals manufacture to a more sustainable biomass-based production is discussed.

1,095 citations

Journal ArticleDOI
TL;DR: In this article, the authors describe the development of two of those education tools, which are used to influence and improve the environmental performance of a large multi-national pharmaceutical company by using electronic education tools.

845 citations

Journal ArticleDOI
TL;DR: The role of catalysis in waste minimisation is discussed and illustrated with examples of green catalytic processes such as aerobic oxidations of alcohols, catalytic C-C bond formation and olefin metathesis as discussed by the authors.

798 citations

Journal ArticleDOI
TL;DR: A new (bpy)Cu(I)/TEMPO catalyst system that enables efficient and selective aerobic oxidation of a broad range of primary alcohols to the corresponding aldehydes using readily available reagents, at room temperature with ambient air as the oxidant.
Abstract: Aerobic oxidation reactions have been the focus of considerable attention, but their use in mainstream organic chemistry has been constrained by limitations in their synthetic scope and by practical factors, such as the use of pure O2 as the oxidant or complex catalyst synthesis. Here, we report a new (bpy)CuI/TEMPO catalyst system that enables efficient and selective aerobic oxidation of a broad range of primary alcohols, including allylic, benzylic, and aliphatic derivatives, to the corresponding aldehydes using readily available reagents, at room temperature with ambient air as the oxidant. The catalyst system is compatible with a wide range of functional groups and the high selectivity for 1° alcohols enables selective oxidation of diols that lack protecting groups.

619 citations

Journal ArticleDOI

606 citations