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Anthony M. C. Brown
Researcher at Cornell University
Publications - 92
Citations - 10320
Anthony M. C. Brown is an academic researcher from Cornell University. The author has contributed to research in topics: Wnt signaling pathway & LRP6. The author has an hindex of 52, co-authored 91 publications receiving 9932 citations. Previous affiliations of Anthony M. C. Brown include University of Medicine and Dentistry of New Jersey & New York Medical College.
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Journal Article
Transformation by Wnt family proteins correlates with regulation of beta-catenin.
Hiroyuki Shimizu,Martin A. Julius,Marianna Giarré,Zhili Zheng,Anthony M. C. Brown,Jan Kitajewski +5 more
TL;DR: It is demonstrated that several Wnt family members are capable of elevating beta-catenin levels and suggested that their signaling pathways share intracellular signaling components and imply the existence of receptors that respond to certain Wnt proteins but not to others.
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Activation of pS2 gene transcription is a primary response to estrogen in the human breast cancer cell line MCF-7.
TL;DR: It is demonstrated that expression of the pS2 gene is controlled by estrogen at the transcriptional level using in vitro nuclear run-on transcription with nuclei prepared from MCF-7 cells grown in the presence ofEstradiol or in estradiol-stripped medium.
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Wnt-1 regulation of connexin43 in cardiac myocytes
TL;DR: It is demonstrated that Wnt signaling is an important modulator of Cx43-dependent intercellular coupling in the heart, and they support the hypothesis that dysregulated signaling contributes to altered impulse propagation and arrhythmia in the myopathic heart.
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Cyclooxygenase-2: a target for the prevention and treatment of breast cancer.
TL;DR: The potential utility of selective COx-2 inhibitors for the prevention and treatment of breast cancer is considered and the mechanisms by which COX-2 is upregulated in cancers and contributes to tumorigenesis are discussed.