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Anthony Rongvaux
Researcher at Fred Hutchinson Cancer Research Center
Publications - 58
Citations - 7469
Anthony Rongvaux is an academic researcher from Fred Hutchinson Cancer Research Center. The author has contributed to research in topics: Immune system & Haematopoiesis. The author has an hindex of 31, co-authored 51 publications receiving 6058 citations. Previous affiliations of Anthony Rongvaux include Regeneron & Bill & Melinda Gates Foundation.
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Journal ArticleDOI
Development and function of human innate immune cells in a humanized mouse model
Anthony Rongvaux,Tim Willinger,Jan Martinek,Till Strowig,Sofia V Gearty,Lino L. Teichmann,Yasuyuki Saito,Florentina Marches,Stephanie Halene,A. Karolina Palucka,Markus G. Manz,Richard A. Flavell +11 more
TL;DR: Two mouse strains called MITRG and MISTRG are described, in which human versions of four genes encoding cytokines important for innate immune cell development are knocked into their respective mouse loci, which may enable evaluation of therapeutic candidates in an in vivo setting relevant to human physiology.
Journal ArticleDOI
The fate and lifespan of human monocyte subsets in steady state and systemic inflammation.
Amit Patel,Yan Zhang,James N. Fullerton,Lies Boelen,Anthony Rongvaux,Alexander A. Maini,Bigley,Richard A. Flavell,Richard A. Flavell,Derek W. Gilroy,Becca Asquith,Derek C. Macallan,Derek C. Macallan,Simon Yona +13 more
TL;DR: It is demonstrated that classical monocytes emerge first from marrow, after a postmitotic interval of 1.6 d, and circulate for a day, which is consistent with a model of sequential transition.
Journal ArticleDOI
Control of TH17 cells occurs in the small intestine.
Enric Esplugues,Enric Esplugues,Enric Esplugues,Samuel Huber,Samuel Huber,Nicola Gagliani,Anja E. Hauser,Terrence Town,Terrence Town,Yisong Y. Wan,William T. O'Connor,Anthony Rongvaux,Nico van Rooijen,Ann M. Haberman,Yoichiro Iwakura,Vijay K. Kuchroo,Jay K. Kolls,Jeffrey A. Bluestone,Kevan C. Herold,Richard A. Flavell,Richard A. Flavell +20 more
TL;DR: It is shown that pro-inflammatory TH17 cells can be redirected to and controlled in the small intestine, and mechanisms limiting TH17 cell pathogenicity are identified and implicate the gastrointestinal tract as a site for control of TH 17 cells.
Journal ArticleDOI
Apoptotic Caspases Prevent the Induction of Type I Interferons by Mitochondrial DNA
Anthony Rongvaux,Ruaidhri Jackson,Christian C. D. Harman,Tuo Li,A. Phillip West,Marcel R. de Zoete,Marcel R. de Zoete,Youtong Wu,Brian Yordy,Saquib A. Lakhani,Chia-Yi Kuan,Tadatsugu Taniguchi,Gerald S. Shadel,Zhijian J. Chen,Zhijian J. Chen,Akiko Iwasaki,Akiko Iwasaki,Richard A. Flavell,Richard A. Flavell +18 more
TL;DR: The results show that mitochondria have the capacity to simultaneously expose a cell-intrinsic inducer of the IFN response and to inactivate this response in a caspase-dependent manner, which provides a dual control, which determines whether mitochondria initiate an immunologically silent or a proinflammatory type of cell death.
Journal ArticleDOI
Pre-B-cell colony-enhancing factor, whose expression is up-regulated in activated lymphocytes, is a nicotinamide phosphoribosyltransferase, a cytosolic enzyme involved in NAD biosynthesis.
Anthony Rongvaux,Robin J. Shea,Martha H. Mulks,Daniel Gigot,Jacques Urbain,Oberdan Leo,Fabienne Andris +6 more
TL;DR: It is demonstrated that the murine homologue of the previously identified human "pre‐B‐cell colony‐enhancing factor" (PBEF) gene coding for a putative cytokine has been identified by screening a subtractive library enriched in genes expressed in activated T lymphocytes, and NAD biosynthesis may play an important role in lymphocyte activation.