Anthony S. Basile

TL;DR: This review will evaluate the basic pharmacology and molecular biology of the PBR, and highlight its role in regulating mitochondrial function, the mitochondrial transmembrane potential and its sensitivity to reactive oxygen species (ROS), and neurosteroid synthesis, processes relevant to the pathogenesis of a number of neurological and neuropsychiatric disorders.

TL;DR: Release studies with brain slices from M2 and M4 receptor single KO mice indicated that autoinhibition of ACh release is mediated primarily by the M2 receptor in hippocampus and cerebral cortex, but predominantly by theM4 receptor in the striatum.

TL;DR: The effects of transient global ischemia using bilateral carotid artery occlusion on regional cytokine levels in gerbil brain were investigated using enzyme-linked immunoassay techniques.

TL;DR: Data indicate a scenario by which microglia activated by sAPP release excitotoxic levels of glutamate, probably as a consequence of autoprotective antioxidant glutathione production within themicroglia, ultimately causing synaptic degeneration and neuronal death.

TL;DR: Results provide unambiguous evidence that multiple mAChR subtypes are involved in the regulation of striatal dopamine release and should contribute to a better understanding of the important functional roles that the muscarinic cholinergic system plays in striatal function.