Anthony S Findley

TL;DR: Directed genetic modification of lactic acid bacteria through ssDNA recombineering will simplify strain improvement in a way that, when mutating a single base, is genetically indistinguishable from strains obtained through directed evolution.

TL;DR: The results suggest that specific microbes play an important role in regulating expression of individual host genes involved in human complex traits.

TL;DR: The results suggest that specific microbes play an important role in regulating expression of individual host genes involved in human complex traits, and the ability to fine tune the expression of host genes by manipulating the microbiome suggests future therapeutic routes.

TL;DR: For example, Findley et al. as mentioned in this paper found that around half of the effects due to an interaction between genetics and the environment and had not been seen in other larger studies of the transcriptome.

TL;DR: It is demonstrated that RNA processing is dramatically changed in response to environmental perturbations through specific mechanisms regulated by trans factors, including splicing factor binding and transcription factors.