António F. Ambrósio

TL;DR: In this article, the effects of IL-1β and TNF-α on retinal endothelial cell permeability were compared and the molecular mechanisms by which TNFα increases cell leakage were elucidated, which suggests that PKCζ may provide a specific therapeutic target for the prevention of vascular permeability in retinal diseases characterized by elevated TNF, including diabetic retinopathy.

TL;DR: The available data indicate that the anticonvulsant efficacy of these AEDs is mainly due to the inhibition of sodium channel activity, which is in line with previous reports on these drugs.

TL;DR: The results indicate that the iNOS isoform plays a predominant role in leukostasis and BRB breakdown, and the mechanism involves ICAM-1 upregulation and tight junction protein downregulation.

TL;DR: An overview of the roles of microglia-mediated neuroinflammation in major retinal degenerative diseases like glaucoma, age-related macular degeneration, and diabetic retinopathy is given.

TL;DR: The role of mitochondrial dysfunction in disorders such as amyotrophic lateral sclerosis, Alzheimer's, Huntington’s and Parkinson's diseases, as well as eye diseases such as age-related macular degeneration and glaucoma, and the causative factors leading to PINK1/PARKIN-mediated neurodegeneration and neuroinflammation are debated.