António J. Santinha

TL;DR: A single transcript encoding Cas12a and an array of CRISPR RNAs enables multiplexed genome engineering, from multiple knockouts to transcriptional activation or repression to orthogonal transcriptional control and editing in the same sample.

TL;DR: In vivo CRISPR screens will continue to fuel progress towards identifying genetic elements controlling development, health, and disease, taking into account complex cellular interactions, immune response, extracellular matrix, and tissue architecture.

TL;DR: In this article, the authors link the connectome and transcriptome in developing single inter-areal cortical projection neurons (ICPN) of the mouse neocortex using a combination of multiplexed analysis of projections by sequencing.

TL;DR: In this paper , the authors identify two oSVZ-expressed microRNAs (miRNAs), miR137 and miR-122, which regulate key cellular features of cortical expansion, such as basal progenitor self-replication and superficial layer neuron fate.

TL;DR: In this article, the authors identify two ferret and human OSVZ-enriched microRNAs (miR, miR-137 and miR,122) which regulate key cellular features associated with cortical expansion.