Author
Antonio Monge-Vega
Bio: Antonio Monge-Vega is an academic researcher from University of Navarra. The author has contributed to research in topics: Trypanosoma cruzi & Salicylaldehyde. The author has an hindex of 3, co-authored 4 publications receiving 245 citations.
Papers
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TL;DR: Results showed that structural modifications on the semicarbazone moiety could have a significant effect on the anti-tumor activity of the vanadium complexes, and no apparent correlation could be demonstrated between reduction potentials of the complexes and their anti-Tumor activities.
113 citations
TL;DR: Quinoxaline derivatives presented good inhibitor activity of growth of Trypanosoma cruzi in in vitro assays and a multiple correlation between activity and lipophilic properties and LUMO energy was established.
84 citations
TL;DR: Several new 1,2,5-oxadiazole N-oxide derivatives and some deoxygenated analogues were synthesized to be tested as potential selective hypoxic cell cytotoxins and proved to be non-selective.
57 citations
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TL;DR: This work reviews the medicinal applications proposed for vanadium compounds with particular emphasis on the more recent publications and concludes that the potential ofVanadium compounds to treat type 2 diabetes is still an open question and therapies using vanadium compound for e.g. antitumor and anti-parasitic related diseases remain promising.
373 citations
TL;DR: In this review the State of the Art will be presented, which includes a summary of the progress made over the past years in the knowledge of the structure and mechanism of the quinoxaline and quInoxaline derivatives, associated medical and biomedical value as well as industrial value.
281 citations
TL;DR: A series of synthetic chalcones, flavanones, and flavones has been synthesized and evaluated for antitumor activity against the human kidney carcinoma cells TK-10, human mammary adenocarcinoma cells MCF-7 (estrogen receptor-positive), and human colon adenOCarcinomas cells HT-29.
270 citations
TL;DR: The triazole Schiff bases and their oxovanadium(IV) complexes have been studied for in vitro antibacterial activity against four Gram-negative and two Gram-positive bacterial strains, in vitro antifungal activity against Trichophyton longifucus, Candida albican, Aspergillus flavus, Microscopum canis, Fusarium solani and Candida glaberata.
257 citations
TL;DR: The first anionic tetrazole-2N-oxide has been prepared by mild aqueous oxidation of easily prepared 5-nitrotetrazole with commercially available oxone in high yields and shows superior energetic performance as calculated by the EXPLO5 computer code.
Abstract: The first anionic tetrazole-2N-oxide has been prepared by mild aqueous oxidation of easily prepared 5-nitrotetrazole with commercially available oxone in high yields. The result of protonating 5-nitrotetrazolate-2N-oxide has been identified as a hydroxytetrazole, and the nitrogen-rich salts including ammonium, hydroxylammonium, guanidinium, aminoguanidinum, diaminoguanidinium, and triaminoguanidinium have been prepared and characterized. When compared to the nitrogen-rich salts of nitrotetrazole, the nitrogen-rich salts of nitrotetrazole-2N-oxide show superior energetic performance as calculated by the EXPLO5 computer code, using heats of formation calculated using the CBS-4M level of quantum mechanical theory. The impact, friction, and electrical spark sensitivities of the nitrogen-rich nitrotetrazolate-2N-oxides were measured and cover the whole range from sensitive to insensitive energetic materials.
255 citations