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Antonio Muñoz

Bio: Antonio Muñoz is an academic researcher from Complutense University of Madrid. The author has contributed to research in topics: Electron scattering & Monte Carlo method. The author has an hindex of 17, co-authored 51 publications receiving 1362 citations. Previous affiliations of Antonio Muñoz include University of Erlangen-Nuremberg & Pontifical University of Salamanca.


Papers
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Journal ArticleDOI
TL;DR: Water-soluble tridecafullerenes decorated with 120 peripheral carbohydrate subunits, so-called 'superballs', that can be synthesized efficiently from hexakis adducts of [60]fullerene in one step by using copper-catalysed azide–alkyne cycloaddition click chemistry are reported.
Abstract: The use of multivalent carbohydrate compounds to block cell-surface lectin receptors is a promising strategy to inhibit the entry of pathogens into cells and could lead to the discovery of novel antiviral agents. One of the main problems with this approach, however, is that it is difficult to make compounds of an adequate size and multivalency to mimic natural systems such as viruses. Hexakis adducts of [60]fullerene are useful building blocks in this regard because they maintain a globular shape at the same time as allowing control over the size and multivalency. Here we report water-soluble tridecafullerenes decorated with 120 peripheral carbohydrate subunits, so-called 'superballs', that can be synthesized efficiently from hexakis adducts of [60]fullerene in one step by using copper-catalysed azide–alkyne cycloaddition click chemistry. Infection assays show that these superballs are potent inhibitors of cell infection by an artificial Ebola virus with half-maximum inhibitory concentrations in the subnanomolar range.

229 citations

Journal ArticleDOI
TL;DR: Fullerene hexakis-adducts bearing 12 peripheral carbohydrate moieties have been prepared by grafting sugar derivatives onto the fullerene core through the copper mediated Huisgen 1,3-dipolar cycloaddition of azides and alkynes.

158 citations

Journal ArticleDOI
TL;DR: Electron scattering cross sections for pyridine in the energy range 0–100 eV have been critically compiled and complemented here with new measurements of electron energy loss spectra and double differential ionization cross sections.
Abstract: Electron scattering cross sections for pyridine in the energy range 0–100 eV, which we previously measured or calculated, have been critically compiled and complemented here with new measurements of electron energy loss spectra and double differential ionization cross sections. Experimental techniques employed in this study include a linear transmission apparatus and a reaction microscope system. To fulfill the transport model requirements, theoretical data have been recalculated within our independent atom model with screening corrected additivity rule and interference effects (IAM-SCAR) method for energies above 10 eV. In addition, results from the R-matrix and Schwinger multichannel with pseudopotential methods, for energies below 15 eV and 20 eV, respectively, are presented here. The reliability of this complete data set has been evaluated by comparing the simulated energy distribution of electrons transmitted through pyridine, with that observed in an electron-gas transmission experiment under magnetic confinement conditions. In addition, our representation of the angular distribution of the inelastically scattered electrons is discussed on the basis of the present double differential cross section experimental results.

151 citations

Journal ArticleDOI
TL;DR: The results obtained in these experiments demonstrate for the first time that these glycoconjugates are adequate to inhibit efficiently an infection process, and therefore, they can be considered as very promising and interesting tools to interfere in biological events where lectins such as DC-SIGN are involved.

126 citations

Journal ArticleDOI
TL;DR: This paper aims to demonstrate the efforts towards in-situ applicability of EMMARM, which aims to provide real-time information about the response of the immune system to EMTs.
Abstract: Financial support by the MICINN of Spain (CTQ2008-00795/BQU, CTQ2008-01694), the CAM (MADRISOLAR-2 S2009/PPQ-1533), Consolider- Ingenio (CSD2007-00010, Nanociencia Molecular), and the EU (FUNMOL FP7-212942-1) is greatly appreciated. A.M. thanks the MICINN for an FPI Studentship

84 citations


Cited by
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Journal ArticleDOI
TL;DR: The main findings are that socio-economic drivers have favoured land cover changes contributing to increasing fire hazard in the last decades, and large wildfires are becoming more frequent and increased fire frequency is promoting homogeneous landscapes covered by fire-prone shrublands.

662 citations

Journal ArticleDOI
TL;DR: By interfering with pathogen adhesion, such glycocompounds including glycopolymers, glycoclusters, glycodendrimers and glyconanoparticles have the potential to improve or replace antibiotic treatments that are now subverted by resistance.
Abstract: Multivalency plays a major role in biological processes and particularly in the relationship between pathogenic microorganisms and their host that involves protein-glycan recognition. These interactions occur during the first steps of infection, for specific recognition between host and bacteria, but also at different stages of the immune response. The search for high-affinity ligands for studying such interactions involves the combination of carbohydrate head groups with different scaffolds and linkers generating multivalent glycocompounds with controlled spatial and topology parameters. By interfering with pathogen adhesion, such glycocompounds including glycopolymers, glycoclusters, glycodendrimers and glyconanoparticles have the potential to improve or replace antibiotic treatments that are now subverted by resistance. Multivalent glycoconjugates have also been used for stimulating the innate and adaptive immune systems, for example with carbohydrate-based vaccines. Bacteria present on their surfaces natural multivalent glycoconjugates such as lipopolysaccharides and S-layers that can also be exploited or targeted in anti-infectious strategies.

449 citations

Journal ArticleDOI
TL;DR: This seminar article has covered the various reports that have been published on the clinical usage of honey and recommended that clinicians should look for the clinicalevidence that exists to support the use of other wound care products to compare with the evidence that exists for honey.
Abstract: Somecliniciansareundertheimpressionthatthereislittleor no evidence to support the use of honey as a wound dressing. To allow sound decisions to be made, this seminar article has covered the various reports that have been published on the clinical usage of honey. Positive findings on honey in wound carehavebeenreportedfrom17randomizedcontrolledtrials involving a total of 1965 participants, and 5 clinical trials of otherformsinvolving97participantstreatedwithhoney.The effectiveness of honey in assisting wound healing has also been demonstrated in 16 trials on a total of 533 wounds on experimental animals. There is also a large amount of evidence in the form of case studies that have been reported. It has been shown to give good results on a very wide range of typesofwound.Itisthereforemystifyingthatthereappearsto be a lack of universal acceptance of honey as a wound dressing. It is recommended that clinicians should look for the clinical evidence that exists to support the use of other wound care products to compare with the evidence that exists for honey.

398 citations