Author
Antonio Sabatini
Other affiliations: University of Bologna
Bio: Antonio Sabatini is an academic researcher from University of Florence. The author has contributed to research in topics: Crystal structure & Potentiometric titration. The author has an hindex of 22, co-authored 48 publications receiving 7158 citations. Previous affiliations of Antonio Sabatini include University of Bologna.
Papers
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TL;DR: A new suite of 10 programs concerned with equilibrium constants and solution equilibria is described, which includes data preparation programs, pretreatment programs, equilibrium constant refinement and post-run analysis.
2,779 citations
TL;DR: Hyperquad simulation and speciation (HySS) as mentioned in this paper is a computer program written for the Windows operating system on personal computers which provides simulating titration curves and a system for providing speciation diagrams.
1,400 citations
TL;DR: In this article, a computer program was developed in which formation constants were determined by minimisation of an error-square sum based on measured electrode potentials, allowing refinement of any reactant concentration or standard electrode potential.
Abstract: A new computer program has been developed in which formation constants are determined by minimisation of an error-square sum based on measured electrode potentials. The program also permits refinement of any reactant concentration or standard electrode potential. The refinement is incorporated into a new procedure which can be used for model selection.
952 citations
TL;DR: A new computer programme for the computation of formation constants of complex species in solution is presented, which can be applied to all kinds of potentiometric titration data, including multi-reactant and multi-electrode systems.
434 citations
TL;DR: A calculation procedure of general validity has been developed to unravel the effect of rapid exchange between the various species in equilibrium as a function of pD of the solution to obtain basicity constants of spermine with respect to the D+ cation at 40 degrees C.
411 citations
Cited by
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TL;DR: A new suite of 10 programs concerned with equilibrium constants and solution equilibria is described, which includes data preparation programs, pretreatment programs, equilibrium constant refinement and post-run analysis.
2,779 citations
TL;DR: Hyperquad simulation and speciation (HySS) as mentioned in this paper is a computer program written for the Windows operating system on personal computers which provides simulating titration curves and a system for providing speciation diagrams.
1,400 citations
TL;DR: The orange-red deprotonated urea solution uptakes carbon dioxide from air to give the tetrabutylammonium salt of the hydrogencarbonate H-bond complex, [Bu4N][1.HCO3], whose crystal and molecular structures have been determined.
Abstract: 1,3-bis(4-nitrophenyl)urea (1) interacts through hydrogen bonding with a variety of oxoanions in an MeCN solution to give bright yellow 1:1 complexes, whose stability decreases with the decreasing basicity of the anion (CH3COO- > C6H5COO- > H2PO4- > NO2- > HSO4- > NO3-). The [Bu4N][1·CH3COO] complex salt has been isolated as a crystalline solid and its molecular structure determined, showing the formation of a discrete adduct held together by two N−H···O hydrogen bonds of moderate strength. On the other hand, the F- ion first establishes a hydrogen-bonding interaction with 1 to give the most stable 1:1 complex, and then on addition of a second equivalent, induces urea deprotonation, due to the formation of HF2-. The orange-red deprotonated urea solution uptakes carbon dioxide from air to give the tetrabutylammonium salt of the hydrogencarbonate H-bond complex, [Bu4N][1·HCO3], whose crystal and molecular structures have been determined.
767 citations
676 citations
TL;DR: An unusual buried metal-receptor site in CueR restricts the metal to a linear, two-coordinate geometry and uses helix-dipole and hydrogen-bonding interactions to enhance metal binding, which is rare among metalloproteins but well suited for an ultrasensitive genetic switch.
Abstract: The earliest of a series of copper efflux genes in Escherichia coli are controlled by CueR, a member of the MerR family of transcriptional activators. Thermodynamic calibration of CueR reveals a zeptomolar (10(-21) molar) sensitivity to free Cu+, which is far less than one atom per cell. Atomic details of this extraordinary sensitivity and selectivity for +1transition-metal ions are revealed by comparing the crystal structures of CueR and a Zn2+-sensing homolog, ZntR. An unusual buried metal-receptor site in CueR restricts the metal to a linear, two-coordinate geometry and uses helix-dipole and hydrogen-bonding interactions to enhance metal binding. This binding mode is rare among metalloproteins but well suited for an ultrasensitive genetic switch.
622 citations