Aparajita Chowdhury

TL;DR: The data strongly supports a non-linear dose response for the effects of inorganic arsenic, and in various in vitro and in vivo models and in human epidemiology studies there appears to be a threshold for biological responses, including cancer.

TL;DR: It is proposed that the KIBRA-Aurora-Lats2 protein complexes form a novel axis that regulates precise mitosis, which is consistent with playing a role in mitosis.

TL;DR: This work demonstrates for the first time that TGFβ receptor reconstitution leads to decreased metastatic colonization and indicates the clinical potential for developing anti-metastasis therapy based on inhibition of this very important aberrant cell survival mechanism by the multifaceted TGF β/PKA transduceome induced pathway.

TL;DR: Patients exhibiting high survivin expression with epigenetically silenced TGFβRII with concomitant survivin repression may represent a significant mechanism in the anticancer effects of this drug, and might potentially benefit from the use of this histone deacetylase inhibitor.

TL;DR: It is demonstrated that treatment with MK-8745 leads to cell cycle arrest at the G2/M phase with accumulation of tetraploid nuclei followed by cell death in non-Hodgkin lymphoma (NHL) cell lines, and results indicate that TPX2 may serve as a biomarker for identifying subpopulations of patients sensitive to Aurora-A inhibitor treatment.