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April D. Pyle
Researcher at University of California, Los Angeles
Publications - 70
Citations - 6314
April D. Pyle is an academic researcher from University of California, Los Angeles. The author has contributed to research in topics: Stem cell & Induced pluripotent stem cell. The author has an hindex of 28, co-authored 61 publications receiving 5691 citations. Previous affiliations of April D. Pyle include University of California, Berkeley & Johns Hopkins University.
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Journal ArticleDOI
Generation of human induced pluripotent stem cells from dermal fibroblasts
William E. Lowry,Laura Richter,Robin Yachechko,April D. Pyle,Jason Tchieu,Rupa Sridharan,Amander T. Clark,Kathrin Plath +7 more
TL;DR: Methods to use dermal fibroblasts easily obtained from an individual human to generate human induced pluripotent stem (iPS) cells by ectopic expression of the defined transcription factors KLF4, OCT4, SOX2, and C-MYC are described.
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Induced Pluripotent Stem Cells and Embryonic Stem Cells Are Distinguished by Gene Expression Signatures
Mark H. Chin,Michael Mason,Wei Xie,Stefano Volinia,Michael A. Singer,Cory Peterson,G. Ambartsumyan,Otaren Aimiuwu,Laura Richter,Jin Zhang,Ivan Khvorostov,Vanessa Ott,Michael Grunstein,Neta Lavon,Nissim Benvenisty,Carlo M. Croce,Amander T. Clark,Tim Baxter,April D. Pyle,Michael A. Teitell,Matteo Pelegrini,Kathrin Plath,William E. Lowry +22 more
TL;DR: Genome-wide data and high-resolution array profiling demonstrated that there is no common specific subkaryotypic alteration that is required for reprograming and that reprogramming does not lead to genomic instability, and suggest that iPSCs should be considered a unique subtype of pluripotent cell.
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Proliferative Neural Stem Cells Have High Endogenous ROS Levels that Regulate Self-Renewal and Neurogenesis in a PI3K/Akt-Dependant Manner
Janel E. Le Belle,Nicolas M. Orozco,Andres A. Paucar,Jonathan P. Saxe,Jack Mottahedeh,April D. Pyle,Hong Wu,Harley I. Kornblum +7 more
TL;DR: This study has identified a redox-mediated regulatory mechanism of NSC function that may have significant implications for brain injury, disease, and repair.
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Defining the Role of Wnt/β-Catenin Signaling in the Survival, Proliferation, and Self-Renewal of Human Embryonic Stem Cells
Gautam Dravid,Zhaohui Ye,Holly Hammond,Guibin Chen,April D. Pyle,Peter J. Donovan,Xiaobing Yu,Linzhao Cheng +7 more
TL;DR: It is found that supportive feeder cells secrete growth factors required for both h ESC survival/proliferation and blocking hESC spontaneous differentiation to achieve self‐renewal, and proposes a new model for the role of Wnt/β‐catenin signaling in undifferentiated hESCs.
Journal ArticleDOI
A Single CRISPR-Cas9 Deletion Strategy that Targets the Majority of DMD Patients Restores Dystrophin Function in hiPSC-Derived Muscle Cells
Courtney S. Young,Michael R. Hicks,Natalia Ermolova,Haruko Nakano,Majib Jan,Majib Jan,Shahab Younesi,Shahab Younesi,Saravanan Karumbayaram,Chino Kumagai-Cresse,Derek W. Wang,Jerome A. Zack,Donald B. Kohn,Atsushi Nakano,Stanley F. Nelson,M. Carrie Miceli,Melissa J. Spencer,April D. Pyle +17 more
TL;DR: The feasibility of using a single CRISPR pair to correct the reading frame for the majority of DMD patients is demonstrated as demonstrated by improved membrane integrity and restoration of the dystrophin glycoprotein complex in vitro and in vivo.