Aradhana Katke

TL;DR: This work reports the first direct observation of the internalization of probes by a living cell, the accurate measurement of the "fluid phase" cytoplasmic viscosity of ~ 200 cP for a HeLa cell, and demonstration of intracellular measurements in cells derived from human patients, which establish the strength of this novel technique for measurements in both intra- and extracellular environments.

TL;DR: VO_IsoR plans are superior in sparing the normal structures while also providing better conformity and homogeneity to the target in this retrospective study of cervix HDR interstitial brachytherapy implants planned using geometric optimization and treated with 6 Gy per fraction.

TL;DR: In this study of locally advanced oropharyngeal carcinoma treated with radical radiotherapy comparing concurrent chemotherapy with cisplatin weekly vs 3 weekly had no significant difference in overall response, complete response and acute toxicities.

TL;DR: The development of the mathematical model using Penne's bio-heat transfer equation, and the estimation of the location and the size of the tumour using Metropolis-Hasting (MH) algorithm and the pre-processing of the thermal images using RGB max filter and Grab-cut algorithm.

Abstract: Background: The outcome of chemoradiotherapy in patients with locally advanced cervical carcinoma is highly variable and depends on various prognostic factors. Objectives: The aim of this study is to evaluate the prevalence and prognostic significance of thrombocytosis in this group of the patients referred to our institution. Methods: Between January 2008 and December 2012, 195 patients with locally advanced cervical carcinoma (International Federation of Gynecology and Obstetrics (FIGO) stages of IIB-IIIB), treated with external beam radiotherapy (EBRT) to a dose of 45 Gy in 25 fractions along with concurrent chemotherapy (cisplatin 40 mg/m2), followed by HDR brachytherapy EQD2 of 30 Gy. The platelet counts were recorded pre-treatment and during treatment in all the patients. Results: Among the 195 patients, 101 (51.5%) belonged to stage IIB and 94 (48.5%) to stage IIIB. Thrombocytosis (platelet count > 400 × 109/liter) was seen in 31 (15.8%) patients. The overall survival in thrombocytosis group is 41%, which is significantly less than the overall survival of the non-thrombocytosis group, which is 62%. Conclusions: Thrombocytosis is not a frequent finding in patients with locally advanced cervical carcinoma in our population; however, when it is present, it is associated with poor outcome in terms of survival.