A
Archa H. Fox
Researcher at University of Western Australia
Publications - 69
Citations - 8362
Archa H. Fox is an academic researcher from University of Western Australia. The author has contributed to research in topics: Paraspeckles & Paraspeckle. The author has an hindex of 32, co-authored 60 publications receiving 6993 citations. Previous affiliations of Archa H. Fox include University of Dundee & University of Sydney.
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Journal ArticleDOI
An Architectural role for a nuclear noncoding RNA : NEAT1 RNA is essential for the structure of paraspeckles
Christine Moulton Clemson,John N. Hutchinson,Sergio A. Sara,Alexander W. Ensminger,Alexander W. Ensminger,Archa H. Fox,Andrew Chess,Jeanne B. Lawrence +7 more
TL;DR: Results demonstrate that NEAT1 functions as an essential structural determinant of paraspeckles, providing a precedent for a ncRNA as the foundation of a nuclear domain.
Journal ArticleDOI
Directed proteomic analysis of the human nucleolus.
Jens S. Andersen,Carol E. Lyon,Archa H. Fox,Anthony K.L. Leung,Yun Wah Lam,Hanno Steen,Matthias Mann,Angus I. Lamond +7 more
TL;DR: This extensive proteomic analysis of human nucleoli shows that nucleoli have a surprisingly large protein complexity and supports the view that the nucleolus may perform additional functions beyond its known role in ribosome subunit biogenesis.
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The oestrogen receptor alpha-regulated lncRNA NEAT1 is a critical modulator of prostate cancer
Dimple Chakravarty,Andrea Sboner,Sujit S. Nair,Eugenia G. Giannopoulou,Ruohan Li,Sven Hennig,Juan Miguel Mosquera,Jonathan Pauwels,Kyung Park,Myriam Kossai,Theresa Y. MacDonald,Jacqueline Fontugne,Nicholas Erho,Ismael A. Vergara,Mercedeh Ghadessi,Elai Davicioni,Robert B. Jenkins,Nallasivam Palanisamy,Zhengming Chen,Shinichi Nakagawa,Tetsuro Hirose,Neil H. Bander,Himisha Beltran,Archa H. Fox,Olivier Elemento,Mark A. Rubin +25 more
TL;DR: Nuclear enriched abundant transcript 1 (NEAT1) is identified as the most significantly overexpressed lncRNA in prostate cancer and evidence that NEAT1 drives oncogenic growth by altering the epigenetic landscape of target gene promoters to favour transcription is provided.
Journal ArticleDOI
Paraspeckles: a novel nuclear domain.
Archa H. Fox,Yun Wah Lam,Anthony K.L. Leung,Carol E. Lyon,Jens S. Andersen,Matthias Mann,Angus I. Lamond +6 more
TL;DR: It is shown that PSP1 accumulates in a new nucleoplasmic compartment, termed paraspeckles, that also contains at least two other protein components: PSP2 and p54/nrb.
Journal ArticleDOI
Genome-wide analysis of long noncoding RNA stability
Michael B. Clark,Rebecca L. Johnston,Mario Inostroza-Ponta,Archa H. Fox,Ellen Fortini,Pablo Moscato,Marcel E. Dinger,John S. Mattick +7 more
TL;DR: Analysis of lncRNA features revealed that intergenic and cis-antisense RNAs are more stable than those derived from introns, as are spliced lncRNAs compared to unspliced (single exon) transcripts, as well as lnc RNAs showing extreme stability.