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Ariel Halper-Stromberg
Researcher at Rockefeller University
Publications - 13
Citations - 2312
Ariel Halper-Stromberg is an academic researcher from Rockefeller University. The author has contributed to research in topics: Viral load & Antibody. The author has an hindex of 9, co-authored 11 publications receiving 2033 citations. Previous affiliations of Ariel Halper-Stromberg include Howard Hughes Medical Institute.
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Journal ArticleDOI
Complex-type N-glycan recognition by potent broadly neutralizing HIV antibodies.
Hugo Mouquet,Louise Scharf,Zelda Euler,Yan Liu,Caroline Eden,Johannes F. Scheid,Johannes F. Scheid,Ariel Halper-Stromberg,Priyanthi N. P. Gnanapragasam,Daniel I. R. Spencer,Michael S. Seaman,Hanneke Schuitemaker,Ten Feizi,Michel C. Nussenzweig,Pamela J. Bjorkman +14 more
TL;DR: As HIV envelopes exhibit varying proportions of high-mannose- and complex-type N-glycans, these results suggest promiscuous carbohydrate interactions, an advantageous adaptation ensuring neutralization of all viruses within a given strain.
Journal ArticleDOI
HIV therapy by a combination of broadly neutralizing antibodies in humanized mice
Florian Klein,Ariel Halper-Stromberg,Joshua A. Horwitz,Henning Gruell,Henning Gruell,Johannes F. Scheid,Johannes F. Scheid,Stylianos Bournazos,Hugo Mouquet,Linda Spatz,Linda Spatz,Ron Diskin,Alexander Abadir,Trinity Zang,Marcus Dorner,Eva Billerbeck,Rachael N. Labitt,Christian Gaebler,Christian Gaebler,Paola Marcovecchio,Reha Baris Incesu,Thomas Eisenreich,Paul D. Bieniasz,Paul D. Bieniasz,Michael S. Seaman,Pamela J. Bjorkman,Jeffrey V. Ravetch,Alexander Ploss,Michel C. Nussenzweig,Michel C. Nussenzweig +29 more
TL;DR: Combinations of potent monoclonal antibodies can effectively control HIV-1 replication in humanized mice, and should be re-examined as a therapeutic modality in HIV- 1-infected individuals.
Journal ArticleDOI
Broadly Neutralizing Antibodies and Viral Inducers Decrease Rebound from HIV-1 Latent Reservoirs in Humanized Mice
Ariel Halper-Stromberg,Ching-Lan Lu,Florian Klein,Joshua A. Horwitz,Stylianos Bournazos,Lillian Nogueira,Thomas Eisenreich,Cassie Liu,Anna Gazumyan,Uwe Schaefer,Rebecca C. Furze,Michael S. Seaman,Rab K. Prinjha,Alexander Tarakhovsky,Jeffrey V. Ravetch,Michel C. Nussenzweig,Michel C. Nussenzweig +16 more
TL;DR: It is shown that broadly neutralizing antibodies (bNAbs) can interfere with establishment of a silent reservoir by Fc-FcR-mediated mechanisms, and combinations of inducers and bNAbs constitute a therapeutic strategy that impacts the establishment and maintenance of the HIV-1 reservoir in humanized mice.
Journal ArticleDOI
Enhanced clearance of HIV-1–infected cells by broadly neutralizing antibodies against HIV-1 in vivo
Ching-Lan Lu,Ching-Lan Lu,Dariusz K. Murakowski,Stylianos Bournazos,Till Schoofs,Debolina Sarkar,Ariel Halper-Stromberg,Joshua A. Horwitz,Lilian Nogueira,Jovana Golijanin,Anna Gazumyan,Jeffrey V. Ravetch,Marina Caskey,Arup K. Chakraborty,Michel C. Nussenzweig,Michel C. Nussenzweig +15 more
TL;DR: Lu et al. as mentioned in this paper showed that neutralizing antibodies may be a promising therapy for HIV-1 because of their potential to reduce the viral reservoir, and demonstrated that therapeutic antibody treatment enhanced infected individuals' humoral response against the virus.
Journal ArticleDOI
HIV-1 suppression and durable control by combining single broadly neutralizing antibodies and antiretroviral drugs in humanized mice
Joshua A. Horwitz,Ariel Halper-Stromberg,Hugo Mouquet,Alexander D. Gitlin,Anna Tretiakova,Thomas Eisenreich,Marine Malbec,Sophia Gravemann,Eva Billerbeck,Marcus Dorner,Hildegard Büning,Olivier Schwartz,Elena Knops,Rolf Kaiser,Michael S. Seaman,James M. Wilson,Charles M. Rice,Alexander Ploss,Pamela J. Bjorkman,Florian Klein,Michel C. Nussenzweig +20 more
TL;DR: It is concluded that immunotherapy reduces plasma viral load and cell-associated HIV-1 DNA and that decreasing the initial viral load enables single bNAbs to control viremia in hu-mice.