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Arnab Ray Chaudhuri
Researcher at Erasmus University Medical Center
Publications - 27
Citations - 3622
Arnab Ray Chaudhuri is an academic researcher from Erasmus University Medical Center. The author has contributed to research in topics: DNA replication & Homologous recombination. The author has an hindex of 12, co-authored 24 publications receiving 2651 citations. Previous affiliations of Arnab Ray Chaudhuri include National Institutes of Health & University of Zurich.
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The multifaceted roles of PARP1 in DNA repair and chromatin remodelling
TL;DR: The roles of PARP1 in mediating various aspects of DNA metabolism, such as single-strand break repair, nucleotide excision repair, double-stranded break repair and the stabilization of replication forks, and in modulating chromatin structure are discussed.
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Replication fork stability confers chemoresistance in BRCA-deficient cells
Arnab Ray Chaudhuri,Elsa Callen,Xia Ding,Ewa Gogola,Alexandra A. Duarte,Ji-Eun Lee,Nancy Wong,Vanessa Lafarga,Jennifer A. Calvo,Nicholas J. Panzarino,Sam John,Amanda Day,Anna Vidal Crespo,Binghui Shen,Linda M. Starnes,Julian R. de Ruiter,Jeremy A. Daniel,Panagiotis A. Konstantinopoulos,David Cortez,Sharon B. Cantor,Oscar Fernandez-Capetillo,Kai Ge,Jos Jonkers,Sven Rottenberg,Sven Rottenberg,Shyam K. Sharan,André Nussenzweig +26 more
TL;DR: It is shown that loss of the MLL3/4 complex protein, PTIP, protects Brca1/2- deficient cells from DNA damage and rescues the lethality of Brca2-deficient embryonic stem cells, but PTIP deficiency does not restore homologous recombination activity at double-strand breaks.
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Rad51 protects nascent DNA from Mre11-dependent degradation and promotes continuous DNA synthesis
TL;DR: Direct roles for Rad51 at replication forks are revealed, demonstrating that Rad51 protects newly synthesized DNA from Mre11-dependent degradation and promotes continuous DNA synthesis.
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Topoisomerase I poisoning results in PARP-mediated replication fork reversal
Arnab Ray Chaudhuri,Yoshitami Hashimoto,Raquel Herrador,Kai J. Neelsen,Daniele Fachinetti,Rodrigo Bermejo,Andrea Cocito,Vincenzo Costanzo,Massimo Lopes +8 more
TL;DR: These data identify fork reversal as a means to prevent chromosome breakage upon exogenous replication stress and implicate proteins involved in fork reversal or restart as factors modulating the cytotoxicity of replication stress–inducing chemotherapeutics.
Journal ArticleDOI
Human RECQ1 promotes restart of replication forks reversed by DNA topoisomerase I inhibition
Matteo Berti,Arnab Ray Chaudhuri,Saravanabhavan Thangavel,Shivasankari Gomathinayagam,Saša Kenig,Marko Vujanovic,Federico Odreman,Timo Glatter,Timo Glatter,Simona Graziano,Ramiro Mendoza-Maldonado,Francesca Marino,Bojana Lucic,Valentina Biasin,Matthias Gstaiger,Matthias Gstaiger,Ruedi Aebersold,Ruedi Aebersold,Ruedi Aebersold,Julia M. Sidorova,Raymond J. Monnat,Massimo Lopes,Alessandro Vindigni +22 more
TL;DR: It is shown that the poly(ADP-ribosyl)ation activity of PARP1 stabilizes forks in the regressed state by limiting their restart by RECQ1, and offers molecular perspectives to potentiate chemotherapeutic regimens based on TOP1 inhibition.