A
Arnaud Jacquel
Researcher at French Institute of Health and Medical Research
Publications - 86
Citations - 3903
Arnaud Jacquel is an academic researcher from French Institute of Health and Medical Research. The author has contributed to research in topics: Apoptosis & Cellular differentiation. The author has an hindex of 34, co-authored 78 publications receiving 3375 citations. Previous affiliations of Arnaud Jacquel include University of Burgundy & University of Nice Sophia Antipolis.
Papers
More filters
Journal ArticleDOI
Phosphorylation of Bim-EL by Erk1/2 on serine 69 promotes its degradation via the proteasome pathway and regulates its proapoptotic function.
Frederic Luciano,Arnaud Jacquel,Pascal Colosetti,Magali Herrant,Sebastien Cagnol,Gilles Pagès,Patrick Auberger +6 more
TL;DR: It is reported here that Bim-EL when phosphorylated by Erk1/2 is rapidly degraded via the proteasome pathway, and therefore represents a new and important mechanism of Bim regulation.
Journal ArticleDOI
Inhibiting glutamine uptake represents an attractive new strategy for treating acute myeloid leukemia.
Lise Willems,Lise Willems,Nathalie Jacque,Arnaud Jacquel,Nathalie Neveux,Thiago Trovati Maciel,Mireille Lambert,Alain Schmitt,Laury Poulain,Alexa S. Green,Madalina Uzunov,Olivier Kosmider,Olivier Kosmider,Isabelle Radford-Weiss,Ivan C. Moura,Patrick Auberger,Norbert Ifrah,Valérie Bardet,Valérie Bardet,Nicolas Chapuis,Nicolas Chapuis,Catherine Lacombe,Catherine Lacombe,Patrick Mayeux,Patrick Mayeux,Jerome Tamburini,Jerome Tamburini,Didier Bouscary,Didier Bouscary +28 more
TL;DR: It is shown that glutamine removal inhibits mTORC1 and induces apoptosis in AML cells, and that l-ases upregulate glutamine synthase expression in leukemic cells and that a GS knockdown enhances l-ase-induced apoptotic response in someAML cells.
Journal ArticleDOI
Cleavage of Mcl-1 by caspases impaired its ability to counteract Bim-induced apoptosis.
Magali Herrant,Arnaud Jacquel,Sandrine Marchetti,Nathalie Belhacene,Pascal Colosetti,Frederic Luciano,Patrick Auberger +6 more
TL;DR: It is demonstrated that cleavage of Mcl-1 by caspases modifies its subcellular localization, increases its association with Bim and inhibits its antiapoptotic function.
Journal ArticleDOI
IL-34 and CSF-1 display an equivalent macrophage differentiation ability but a different polarization potential
Sonia Boulakirba,Anja Pfeifer,Rana Mhaidly,Sandrine Obba,Michael Goulard,Thomas Schmitt,Paul Chaintreuil,Anne Calleja,Nathan Furstoss,François Orange,Sandra Lacas-Gervais,Laurent Boyer,Sandrine Marchetti,Els Verhoeyen,Frederic Luciano,Guillaume Robert,Patrick Auberger,Arnaud Jacquel +17 more
TL;DR: It is indicated that CSF-1 and IL-34 exhibit the same ability to induce human monocyte differentiation but may have a different ability to polarize macrophages.
Journal ArticleDOI
Autophagy is required for CSF-1–induced macrophagic differentiation and acquisition of phagocytic functions
Arnaud Jacquel,Sandrine Obba,Laurent Boyer,Laurent Boyer,Maeva Dufies,Guillaume Robert,Pierre Gounon,Emmanuel Lemichez,Emmanuel Lemichez,Frederic Luciano,Eric Solary,Eric Solary,Patrick Auberger +12 more
TL;DR: It is shown here, using pharmacologic inhibitors, siRNA approaches, and Atg7-/- mice, that autophagy initiated by ULK1 is required for proper colony stimulating factor-1-driven differentiation of human and murine monocytes and for macrophage acquisition of phagocytic functions.