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Arne W. Mould
Researcher at University of Oxford
Publications - 47
Citations - 2808
Arne W. Mould is an academic researcher from University of Oxford. The author has contributed to research in topics: Cellular differentiation & Regulation of gene expression. The author has an hindex of 21, co-authored 47 publications receiving 2519 citations. Previous affiliations of Arne W. Mould include University of Queensland & Oxford Health NHS Foundation Trust.
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Journal ArticleDOI
Mice Lacking the Vascular Endothelial Growth Factor-B Gene (Vegfb) Have Smaller Hearts, Dysfunctional Coronary Vasculature, and Impaired Recovery From Cardiac Ischemia
Daniela Bellomo,John P. Headrick,Ginters Silins,Carol Paterson,Penny S. Thomas,Michael Gartside,Arne W. Mould,Marian M. Cahill,Ian D. Tonks,Sean M. Grimmond,Steve Townson,Christine A. Wells,Melissa H. Little,Margaret C. Cummings,Nicholas K. Hayward,Graham F. Kay +15 more
TL;DR: A role for VEGF-B in the development or function of coronary vasculature is revealed and potential clinical use in therapeutic angiogenesis is suggested.
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Relationship between interleukin-5 and eotaxin in regulating blood and tissue eosinophilia in mice.
TL;DR: It is proposed that eotaxin secreted from inflamed tissue may play an important role in initiating both blood and tissue eosinophilia in the early phases of allergic inflammation.
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Aeroallergen-induced eosinophilic inflammation, lung damage, and airways hyperreactivity in mice can occur independently of IL-4 and allergen-specific immunoglobulins.
TL;DR: The results indicate that IL-4 is not essential for the development of IL-5-producing CD4+ T cells or for the induction of eosinophilic inflammation and airways damage and hyperreactivity, and suggest that allergic airways disease can occur via pathways which operate independently ofIL-4 and allergen-specific immunoglobulins.
Journal ArticleDOI
Elemental signals regulating eosinophil accumulation in the lung.
Paul S. Foster,Arne W. Mould,Ming Yang,Jason Mackenzie,Joerg Mattes,Simon P. Hogan,Surendran Mahalingam,Andrew N. J. McKenzie,Marc E. Rothenberg,Ian G. Young,Klaus I. Matthaei,Dianne C. Webb +11 more
TL;DR: There are two interwoven mechanisms for the accumulation of eosinophils in pulmonary tissues and that these mechanisms are linked to the development of airways hyperreactivity (AHR) associated with asthma.
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PCGF3/5–PRC1 initiates Polycomb recruitment in X chromosome inactivation
Mafalda Almeida,Greta Pintacuda,Osamu Masui,Yoko Koseki,Michal R. Gdula,Andrea Cerase,David Brown,Arne W. Mould,Cassandravictoria Innocent,Manabu Nakayama,Lothar Schermelleh,Tatyana B. Nesterova,Haruhiko Koseki,Neil Brockdorff +13 more
TL;DR: It is shown that the noncanonical Polycomb group RING finger 3/5 (PCGF3/5)–PRC1 complex initiates recruitment of both PRC1 and PRC2 in response to XistRNA expression, overturning existing models for Polycomb recruitment by Xist RNA and establishing precedence for H2AK119u1 in initiating Polycomb domain formation in a physiological context.