A
Aroldo Rizzo
Researcher at Queen Mary University of London
Publications - 56
Citations - 2253
Aroldo Rizzo is an academic researcher from Queen Mary University of London. The author has contributed to research in topics: Giant cell arteritis & Inflammation. The author has an hindex of 23, co-authored 52 publications receiving 1780 citations.
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Journal ArticleDOI
Type 3 innate lymphoid cells producing IL-17 and IL-22 are expanded in the gut, in the peripheral blood, synovial fluid and bone marrow of patients with ankylosing spondylitis.
Francesco Ciccia,Giuliana Guggino,Aroldo Rizzo,Laura Saieva,S. Peralta,AnnaRita Giardina,Alessandra Cannizzaro,Guido Sireci,Giacomo De Leo,Riccardo Alessandro,Giovanni Triolo +10 more
TL;DR: Gut-derived IL-17+ and IL-22+ILC3 are expanded in the peripheral blood, SF and inflamed BM of patients with AS, suggesting the presence of an active homing axis between the gut and the inflamed sacroiliac joints.
Journal ArticleDOI
Dysbiosis and zonulin upregulation alter gut epithelial and vascular barriers in patients with ankylosing spondylitis
Francesco Ciccia,Giuliana Guggino,Aroldo Rizzo,Riccardo Alessandro,Michele Maria Luchetti,Simon Milling,Laura Saieva,H. Cypers,Tommaso Stampone,Paola Di Benedetto,Armando Gabrielli,Alessio Fasano,Dirk Elewaut,Giovanni Triolo +13 more
TL;DR: Bacterial ileitis, increased zonulin expression and damaged intestinal mucosal barrier and GVB, characterises the gut of patients with ankylosing spondylitis and are associated with increased blood levels of z onulin, and bacterial products.
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Potential involvement of IL-22 and IL-22-producing cells in the inflamed salivary glands of patients with Sjögren's syndrome
Francesco Ciccia,Giuliana Guggino,Aroldo Rizzo,Angelo Ferrante,Stefania Raimondo,AnnaRita Giardina,Francesco Dieli,Giuseppina Campisi,Riccardo Alessandro,Giovanni Triolo +9 more
TL;DR: The results suggest that, together with IL-17 and IL-23, IL-22 may play a pro-inflammatory role in the pathogenesis of pSS.
Journal ArticleDOI
Chronic myeloid leukemia-derived exosomes promote tumor growth through an autocrine mechanism
Stefania Raimondo,Laura Saieva,Chiara Corrado,Simona Fontana,A. Flugy,Aroldo Rizzo,Giacomo De Leo,Riccardo Alessandro +7 more
TL;DR: CML-derived exosomes promote, through an autocrine mechanism, the proliferation and survival of tumor cells, both in vitro and in vivo, by activating anti-apoptotic pathways, and it is proposed that this mechanism is activated by a ligand-receptor interaction between TGF-β1, found in CML- derived exosome, and the T GF- β1 receptor in C ML cells.
Journal ArticleDOI
Evidence that autophagy, but not the unfolded protein response, regulates the expression of IL-23 in the gut of patients with Ankylosing Spondylitis and subclinical gut inflammation
Francesco Ciccia,A Accardo-Palumbo,Aroldo Rizzo,Giuliana Guggino,Stefania Raimondo,AnnaRita Giardina,Alessandra Cannizzaro,Robert A. Colbert,Riccardo Alessandro,Giovanni Triolo +9 more
TL;DR: The data suggest that HLA-B27 misfolding occurs in the gut of AS patients and is accompanied by activation of autophagy rather than a UPR, which appears to be associated with intestinal modulation of IL-23 in AS.