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Aron H. Lichtman
Researcher at Virginia Commonwealth University
Publications - 242
Citations - 17326
Aron H. Lichtman is an academic researcher from Virginia Commonwealth University. The author has contributed to research in topics: Cannabinoid & Cannabinoid receptor. The author has an hindex of 67, co-authored 232 publications receiving 15821 citations. Previous affiliations of Aron H. Lichtman include Scripps Research Institute & Dartmouth College.
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Journal ArticleDOI
Supersensitivity to anandamide and enhanced endogenous cannabinoid signaling in mice lacking fatty acid amide hydrolase
Benjamin F. Cravatt,Kristin Demarest,Matthew P. Patricelli,Michael H. Bracey,Dan K. Giang,Billy R. Martin,Aron H. Lichtman +6 more
TL;DR: Results indicate that FAAH is a key regulator of anandamide signaling in vivo, setting an endogenous cannabinoid tone that modulates pain perception, and may represent an attractive pharmaceutical target for the treatment of pain and neuropsychiatric disorders.
Journal ArticleDOI
Selective blockade of 2-arachidonoylglycerol hydrolysis produces cannabinoid behavioral effects
Jonathan Z. Long,Weiwei Li,Lamont Booker,James J. Burston,Steven G. Kinsey,Joel E. Schlosburg,Franciso J Pavón,Antonia Serrano,Dana E. Selley,Loren H. Parsons,Aron H. Lichtman,Benjamin F. Cravatt +11 more
TL;DR: 2-AG endogenously modulates several behavioral processes classically associated with the pharmacology of cannabinoids and point to overlapping and unique functions for 2-AG and anandamide in vivo, indicating a functional segregation of endocannabinoid signaling pathways in vivo.
Journal ArticleDOI
Endocannabinoid Hydrolysis Generates Brain Prostaglandins That Promote Neuroinflammation
Daniel K. Nomura,Daniel K. Nomura,Bradley E. Morrison,Jacqueline L. Blankman,Jonathan Z. Long,Steven G. Kinsey,Maria Cecilia Garibaldi Marcondes,Anna M. Ward,Yun Kyung Hahn,Aron H. Lichtman,Bruno Conti,Benjamin F. Cravatt +11 more
TL;DR: These findings identify MAGL as a distinct metabolic node that couples endocannabinoid to prostaglandin signaling networks in the nervous system and suggest that inhibition of this enzyme may be a new and potentially safer way to suppress the proinflammatory cascades that underlie neurodegenerative disorders.
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Chronic monoacylglycerol lipase blockade causes functional antagonism of the endocannabinoid system
Joel E. Schlosburg,Jacqueline L. Blankman,Jonathan Z. Long,Daniel K. Nomura,Bin Pan,Steven G. Kinsey,Peter T. Nguyen,Divya Ramesh,Lamont Booker,James J. Burston,Elizabeth A. Thomas,Dana E. Selley,Laura J. Sim-Selley,Qing-song Liu,Aron H. Lichtman,Benjamin F. Cravatt +15 more
TL;DR: Individual endocannabinoids generate distinct analgesic profiles that are either sustained or transitory and associated with agonism and functional antagonism of the brain cannabinoid system, respectively.
Journal ArticleDOI
Dual blockade of FAAH and MAGL identifies behavioral processes regulated by endocannabinoid crosstalk in vivo
Jonathan Z. Long,Daniel K. Nomura,Robert E. Vann,D. Matthew Walentiny,Lamont Booker,Xin Jin,James J. Burston,Laura J. Sim-Selley,Aron H. Lichtman,Jenny L. Wiley,Benjamin F. Cravatt +10 more
TL;DR: A selective and efficacious dual FAAH/MAGL inhibitor is described and it is shown that this agent exhibits broad activity in the tetrad test for CB1 agonism, causing analgesia, hypomotilty, and catalepsy, indicating that AEA and 2-AG signaling pathways interact to regulate specific behavioral processes in vivo, including those relevant to drug abuse.