A
Arthur Mortha
Researcher at University of Toronto
Publications - 59
Citations - 10552
Arthur Mortha is an academic researcher from University of Toronto. The author has contributed to research in topics: Immune system & Medicine. The author has an hindex of 25, co-authored 46 publications receiving 8360 citations. Previous affiliations of Arthur Mortha include Icahn School of Medicine at Mount Sinai & University of Freiburg.
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Journal ArticleDOI
The dendritic cell lineage: ontogeny and function of dendritic cells and their subsets in the steady state and the inflamed setting.
TL;DR: This review discusses major advances in the understanding of the regulation of DC lineage commitment, differentiation, diversification, and function in situ.
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Tissue-Resident Macrophages Self-Maintain Locally throughout Adult Life with Minimal Contribution from Circulating Monocytes
Daigo Hashimoto,Andrew Chow,Andrew Chow,Clara Noizat,Clara Noizat,Pearline Teo,Mary Beth Beasley,Marylene Leboeuf,Christian Becker,Peter See,Jeremy Price,Daniel Lucas,Melanie Greter,Melanie Greter,Arthur Mortha,Scott W. Boyer,E. Camilla Forsberg,Masato Tanaka,Nico van Rooijen,Adolfo García-Sastre,E. Richard Stanley,Florent Ginhoux,Paul S. Frenette,Miriam Merad +23 more
TL;DR: Results indicate that tissue-resident macrophages and circulating monocytes should be classified as mononuclear phagocyte lineages that are independently maintained in the steady state.
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RORγt and commensal microflora are required for the differentiation of mucosal interleukin 22–producing NKp46 + cells
Stephanie L. Sanos,Viet L. Bui,Viet L. Bui,Arthur Mortha,Karin Oberle,Charlotte Heners,Caroline Johner,Andreas Diefenbach,Andreas Diefenbach +8 more
TL;DR: Evidence is provided that signals from the commensal microflora contribute to the differentiation of a lymphocyte population coexpressing stimulatory natural killer cell receptors and the transcription factor RORγt that produced interleukin 22 (IL-22).
Journal ArticleDOI
Microbiota-dependent crosstalk between macrophages and ILC3 promotes intestinal homeostasis.
Arthur Mortha,Aleksey Chudnovskiy,Daigo Hashimoto,Milena Bogunovic,Sean P. Spencer,Yasmine Belkaid,Miriam Merad +6 more
TL;DR: The cytokine granulocyte-macrophage colony-stimulating factor (GM-CSF), recently renamed Csf2, is a key determinant of myeloid lineage differentiation and is required for the optimal function of tissue MNPs.
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Regulated Expression of Nuclear Receptor RORγt Confers Distinct Functional Fates to NK Cell Receptor-Expressing RORγt+ Innate Lymphocytes
Cedric Vonarbourg,Arthur Mortha,Viet L. Bui,Viet L. Bui,Pedro P. Hernandez,Pedro P. Hernandez,Elina A. Kiss,Thomas Hoyler,Melanie Flach,Bertram Bengsch,Robert Thimme,Christoph Hölscher,Manfred Hönig,Ulrich Pannicke,Klaus Schwarz,Carl F. Ware,Daniela Finke,Andreas Diefenbach +17 more
TL;DR: Using adoptive transfer of genetically tagged LTi-like cells, it is demonstrated that NKR⁻RORγt(+) innate lymphocytes but not NK cells were direct progenitors to NKR(+)RORγT(+) cells in vivo.