抗原变异可使得多种致病微生物易于逃避宿主免疫应答。表达在感染红细胞表面的恶性疟原虫红细胞表面蛋白1（PfPMP1）与感染红细胞、内皮细胞、树突状细胞以及胎盘的单个或多个受体作用，在黏附及免疫逃避中起关键的作用。每个单倍体基因组var基因家族编码约60种成员，通过启动转录不同的var基因变异体为抗原变异提供了分子基础。

疟原虫var基因转换速率变化导致抗原变异[英]／Paul H, Robert P, Christodoulou Z, et al//Proc Natl Acad Sci U S A

Part I. Fundamental Concepts: 1. Introduction and overview 2. Introduction to quantum mechanics 3. Introduction to computer science Part II. Quantum Computation: 4. Quantum circuits 5. The quantum Fourier transform and its application 6. Quantum search algorithms 7. Quantum computers: physical realization Part III. Quantum Information: 8. Quantum noise and quantum operations 9. Distance measures for quantum information 10. Quantum error-correction 11. Entropy and information 12. Quantum information theory Appendices References Index.

Quantum Computation and Quantum Information

A digital computer is generally believed to be an efficient universal computing device; that is, it is believed able to simulate any physical computing device with an increase in computation time by at most a polynomial factor. This may not be true when quantum mechanics is taken into consideration. This paper considers factoring integers and finding discrete logarithms, two problems which are generally thought to be hard on a classical computer and which have been used as the basis of several proposed cryptosystems. Efficient randomized algorithms are given for these two problems on a hypothetical quantum computer. These algorithms take a number of steps polynomial in the input size, e.g., the number of digits of the integer to be factored.

Polynomial-Time Algorithms for Prime Factorization and Discrete Logarithms on a Quantum Computer

The entanglement of a pure state of a pair of quantum systems is defined as the entropy of either member of the pair. The entanglement of formation of a mixed state $\ensuremath{\rho}$ is the minimum average entanglement of an ensemble of pure states that represents \ensuremath{\rho}. An earlier paper conjectured an explicit formula for the entanglement of formation of a pair of binary quantum objects (qubits) as a function of their density matrix, and proved the formula for special states. The present paper extends the proof to arbitrary states of this system and shows how to construct entanglement-minimizing decompositions.

Entanglement of Formation of an Arbitrary State of Two Qubits

All our former experience with application of quantum theory seems to say:
{\it what is predicted by quantum formalism must occur in laboratory} But the
essence of quantum formalism - entanglement, recognized by Einstein, Podolsky,
Rosen and Schr\"odinger - waited over 70 years to enter to laboratories as a
new resource as real as energy This holistic property of compound quantum systems, which involves
nonclassical correlations between subsystems, is a potential for many quantum
processes, including ``canonical'' ones: quantum cryptography, quantum
teleportation and dense coding However, it appeared that this new resource is
very complex and difficult to detect Being usually fragile to environment, it
is robust against conceptual and mathematical tools, the task of which is to
decipher its rich structure This article reviews basic aspects of entanglement including its
characterization, detection, distillation and quantifying In particular, the
authors discuss various manifestations of entanglement via Bell inequalities,
entropic inequalities, entanglement witnesses, quantum cryptography and point
out some interrelations They also discuss a basic role of entanglement in
quantum communication within distant labs paradigm and stress some
peculiarities such as irreversibility of entanglement manipulations including
its extremal form - bound entanglement phenomenon A basic role of entanglement
witnesses in detection of entanglement is emphasized

Quantum entanglement

An unknown quantum state \ensuremath{\Vert}\ensuremath{\varphi}〉 can be disassembled into, then later reconstructed from, purely classical information and purely nonclassical Einstein-Podolsky-Rosen (EPR) correlations. To do so the sender, ``Alice,'' and the receiver, ``Bob,'' must prearrange the sharing of an EPR-correlated pair of particles. Alice makes a joint measurement on her EPR particle and the unknown quantum system, and sends Bob the classical result of this measurement. Knowing this, Bob can convert the state of his EPR particle into an exact replica of the unknown state \ensuremath{\Vert}\ensuremath{\varphi}〉 which Alice destroyed.

https://link.aps.org/pdf/10.1103/PhysRevLett.70.1895

Teleporting an unknown quantum state via dual classical and Einstein-Podolsky-Rosen channels

A quantum system consisting of two subsystems is separable if its density matrix can be written as $\ensuremath{\rho}\phantom{\rule{0ex}{0ex}}=\phantom{\rule{0ex}{0ex}}\ensuremath{\Sigma}{A}^{}{w}_{A}{\ensuremath{\rho}}_{A}^{\ensuremath{'}}\ensuremath{\bigotimes}{\ensuremath{\rho}}_{A}^{\ensuremath{'}\ensuremath{'}},$ where ${\ensuremath{\rho}}_{A}^{\ensuremath{'}}$ and ${\ensuremath{\rho}}_{A}^{\ensuremath{'}\ensuremath{'}}$ are density matrices for the two subsystems, and the positive weights ${w}_{A}$ satisfy $\ensuremath{\Sigma}{w}_{A}\phantom{\rule{0ex}{0ex}}=\phantom{\rule{0ex}{0ex}}1$ In this Letter, it is proved that a necessary condition for separability is that a matrix, obtained by partial transposition of \ensuremath{\rho}, has only non-negative eigenvalues Some examples show that this criterion is more sensitive than Bell's inequality for detecting quantum inseparability

http://www2.fisica.unlp.edu.ar/materias/qc/ppt.pdf

Separability Criterion for Density Matrices.

Preface. Part I: Gathering the Tools. 1. Introduction to Quantum Physics. 2. Quantum Tests. 3. Complex Vector Space. 4. Continuous Variables. Part II: Cryptodeterminism and Quantum Inseparability. 5. Composite Systems. 6. Bell's Theorem. 7. Contextuality. Part III: Quantum Dynamics and Information. 8. Spacetime Symmetries. 9. Information and Thermodynamics. 10. Semiclassical Methods. 11. Chaos and Irreversibility. 12. The Measuring Process. Author Index. Subject Index.

Quantum Theory: Concepts and Methods

This article is concerned with the construction of a quantum-mechanical Hamiltonian describing a computer. This Hamiltonian generates a dynamical evolution which mimics a sequence of elementary logical steps. This can be achieved if each logical step is locally reversible (global reversibility is insufficient). Computational errors due to noise can be corrected by means of redundancy. In particular, reversible error-correcting codes can be embedded in the Hamiltonian itself. An estimate is given for the minimum amount of entropy which must be dissipated at a given noise level and tolerated error rate.

Asher Peres

Papers

Teleporting an unknown quantum state via dual classical and Einstein-Podolsky-Rosen channels

Separability Criterion for Density Matrices.

Quantum Theory: Concepts and Methods

Quantum Theory: Concepts and Methods

Reversible logic and quantum computers.