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Ashoke K. Nandy

Bio: Ashoke K. Nandy is an academic researcher from Indian Institute of Chemical Biology. The author has contributed to research in topics: Triterpene & Orthorhombic crystal system. The author has an hindex of 8, co-authored 9 publications receiving 368 citations.

Papers
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Journal ArticleDOI
TL;DR: A compilation of the triterpenoids isolated during the period 1982–1989 along with their occurrence, available physical data, spectroscopy and X-ray analysis used for their characterization, is included.

85 citations

Journal ArticleDOI
TL;DR: In this article, the structures of a triterpene, belleric acid, and its glucoside, Bellericoside have been defined as 2α,3β,23,24,tetrahydroxyolean-12-en-28-oic acid and its β-d -glucopyranosyl ester.

76 citations

Journal ArticleDOI
TL;DR: A compilation of the triterpenoid saponins isolated during the period from 1987 to mid-1989, together with their occurrence, available physical data and spectroscopy used for their characterization is included.

64 citations

Journal ArticleDOI
TL;DR: It was apparent that in addition to a smaller size and better drug release profile, the contribution of other parameters, e.g. overall surface hydrophilicity or hydrophobicity of the vehicles, also play an important role in the macrophage uptake of the drug.
Abstract: The purpose of the present study was to investigate the therapeutic efficacy of the indigenous drug arjunglucoside I (AG) against in vivo models of experimental leishmaniasis by incorporating it in surface hydrophilic co-polymeric nanogel particles of size less than 100 nm diameter and to compare its efficacy with that of the free drug as well as the drug encapsulated in hydrophobic poly-dl-lactide (PLA) nanoparticles. The drug AG, having glucose at the terminal end of the glycosidic chain, was isolated from an indigenous source. Drug-incorporated ultra-low-sized nanogels (∼90 nm in diameter) composed of cross-linked random co-polymer of N-isopropylacrylamide (NIPAAM) and N-vinyl pyrrolidone(VP) were prepared, characterized and used as delivery vehicles to combat experimental leishmaniasis in hamster models. For comparison, drug-encapsulated hydrophobic nanoparticles (∼250 nm in diameter) made from PLA were used as a control. The drug AG was incorporated in these nanocarriers and these drug-nanocarrier co...

60 citations

Journal ArticleDOI
TL;DR: In this article, two novel acylated triterpenoid bisglycosides isolated from the fruits of Acacia auriculiformis were respectively defined to be 3- O -[β-D-glucopyranosyl (1→6) &{;α-L-arabinopyrano-poly(1→2)&};- β-Dglucophyrano(21)-21-O(2)-O(3)-

32 citations


Cited by
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Journal ArticleDOI
TL;DR: Hydrogel nanoparticles have gained considerable attention in recent years as one of the most promising nanoparticulate drug delivery systems owing to their unique potentials via combining the characteristics of a hydrogel system with a nanoparticle, each with its own advantages and drawbacks.

1,704 citations

Journal ArticleDOI
TL;DR: This review will discuss nanocarriers able to deliver anticancer agents, nucleic acids, proteins and peptides for therapeutic applications by these non-phagocytic routes, starting with the phagocytosis pathway.
Abstract: Nanocarriers offer unique possibilities to overcome cellular barriers in order to improve the delivery of various drugs and drug candidates, including the promising therapeutic biomacromolecules (i.e., nucleic acids, proteins). There are various mechanisms of nanocarrier cell internalization that are dramatically influenced by nanoparticles' physicochemical properties. Depending on the cellular uptake and intracellular trafficking, different pharmacological applications may be considered. This review will discuss these opportunities, starting with the phagocytosis pathway, which, being increasingly well characterized and understood, has allowed several successes in the treatment of certain cancers and infectious diseases. On the other hand, the non-phagocytic pathways encompass various complicated mechanisms, such as clathrin-mediated endocytosis, caveolae-mediated endocytosis and macropinocytosis, which are more challenging to control for pharmaceutical drug delivery applications. Nevertheless, various strategies are being actively investigated in order to tailor nanocarriers able to deliver anticancer agents, nucleic acids, proteins and peptides for therapeutic applications by these non-phagocytic routes.

1,402 citations

Journal ArticleDOI
TL;DR: The potential of one- and two-dimensional NMR techniques for the identification of individual sugar residues, their anomeric configuration, interglycosidic linkages, sequencing and the site of any appended group in establishing the structures of naturally occurring oligosaccharides and glycosides is presented.

1,317 citations

Journal ArticleDOI
TL;DR: In this paper, a compilation of the 13C NMR data of a selected variety of naturally occurring pentacyclic triterpenoids, arranged skeletonwise, is provided.

1,251 citations

Journal ArticleDOI
TL;DR: This work has shown that polyelectrolyte nanogels can readily incorporate oppositely charged low-molecular-mass drugs and biomacromolecules such as oligo- and polynucleotides (siRNA, DNA) as well as proteins.
Abstract: Nanogels are swollen nanosized networks composed of hydrophilic or amphiphilic polymer chains. They are developed as carriers for the transport of drugs, and can be designed to spontaneously incorporate biologically active molecules through formation of salt bonds, hydrogen bonds, or hydrophobic interactions. Polyelectrolyte nanogels can readily incorporate oppositely charged low-molecular-mass drugs and biomacromolecules such as oligo- and polynucleotides (siRNA, DNA) as well as proteins. The guest molecules interact electrostatically with the ionic polymer chains of the gel and become bound within the finite nanogel. Multiple chemical functionalities can be employed in the nanogels to introduce imaging labels and to allow targeted drug delivery. The latter can be achieved, for example, with degradable or cleavable cross-links. Recent studies suggest that nanogels have a very promising future in biomedical applications.

1,069 citations