A
Ashwani Kumar
Researcher at Guru Jambheshwar University of Science and Technology
Publications - 110
Citations - 2204
Ashwani Kumar is an academic researcher from Guru Jambheshwar University of Science and Technology. The author has contributed to research in topics: Quantitative structure–activity relationship & Antimicrobial. The author has an hindex of 21, co-authored 101 publications receiving 1346 citations. Previous affiliations of Ashwani Kumar include Guru Nanak Khalsa College.
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Green synthesis and anticancer potential of chalcone linked-1,2,3-triazoles.
TL;DR: Cell cycle analysis revealed that compound 6h induces apoptosis and G2/S arrest in MIA-Pa-Ca-2 cells and triggers caspase-3 and PARP-1 cleavage, which increases in dose dependent manner.
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Design, synthesis, characterization, antimicrobial evaluation and molecular modeling studies of some dehydroacetic acid-chalcone-1,2,3-triazole hybrids.
TL;DR: A series of new dehydroacetic acid chalcone-1,2,3-triazole hybrids as potential antimicrobial agents was designed, synthesized and characterized by FTIR, NMR and HRMS spectral techniques, indicating that some of the compounds showed remarkable activities comparable to the standard drugs.
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Synthesis, crystal structure and antimicrobial potential of some fluorinated chalcone-1,2,3-triazole conjugates.
Pinki Yadav,Kashmiri Lal,Lokesh Kumar,Ashwani Kumar,Anil Kumar,Avijit Kumar Paul,Rajnish Kumar +6 more
TL;DR: The activity results showed the synergistic effect of biological activity when two pharmacophoric units, i.e. chalcone and 1,2,3-triazole are conjugated.
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Design and development of novel focal adhesion kinase (FAK) inhibitors using Monte Carlo method with index of ideality of correlation to validate QSAR.
TL;DR: The predictive potential of QSAR models of FAK inhibitors was explored by applying the index of ideality of correlation (IIC), which is a new criterion for the prediction of the potential for quantitative structure–property activity relationships (QSPRs/QSARs).
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Synthesis and biological evaluation of amino acid-linked 1,2,3-bistriazole conjugates as potential antimicrobial agents
TL;DR: A small library of amino acid-linked 1,4-disubstituted 1,2,3-bistriazole conjugates has been synthesized from the N-protected l-amino acids propargyl esters through one-pot click reaction, showing good antifungal activity than others against both fungi.