抗原变异可使得多种致病微生物易于逃避宿主免疫应答。表达在感染红细胞表面的恶性疟原虫红细胞表面蛋白1（PfPMP1）与感染红细胞、内皮细胞、树突状细胞以及胎盘的单个或多个受体作用，在黏附及免疫逃避中起关键的作用。每个单倍体基因组var基因家族编码约60种成员，通过启动转录不同的var基因变异体为抗原变异提供了分子基础。

疟原虫var基因转换速率变化导致抗原变异[英]／Paul H, Robert P, Christodoulou Z, et al//Proc Natl Acad Sci U S A

A major problem worldwide is the potential loss of fisheries, forests, and water resources Understanding of the processes that lead to improvements in or deterioration of natural resources is limited, because scientific disciplines use different concepts and languages to describe and explain complex social-ecological systems (SESs) Without a common framework to organize findings, isolated knowledge does not cumulate Until recently, accepted theory has assumed that resource users will never self-organize to maintain their resources and that governments must impose solutions Research in multiple disciplines, however, has found that some government policies accelerate resource destruction, whereas some resource users have invested their time and energy to achieve sustainability A general framework is used to identify 10 subsystem variables that affect the likelihood of self-organization in efforts to achieve a sustainable SES

A General Framework for Analyzing Sustainability of Social-Ecological Systems

The Structural Transformation of the Public Sphere: An Inquiry into a Category of Bourgeois Society

▪ Abstract We explore the social dimension that enables adaptive ecosystem-based management. The review concentrates on experiences of adaptive governance of social-ecological systems during periods of abrupt change (crisis) and investigates social sources of renewal and reorganization. Such governance connects individuals, organizations, agencies, and institutions at multiple organizational levels. Key persons provide leadership, trust, vision, meaning, and they help transform management organizations toward a learning environment. Adaptive governance systems often self-organize as social networks with teams and actor groups that draw on various knowledge systems and experiences for the development of a common understanding and policies. The emergence of “bridging organizations” seem to lower the costs of collaboration and conflict resolution, and enabling legislation and governmental policies can support self-organization while framing creativity for adaptive comanagement efforts. A resilient social-eco...

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Adaptive governance of social-ecological systems

Emerging recognition of two fundamental errors under-pinning past polices for natural resource issues heralds awareness of the need for a worldwide fundamental change in thinking and in practice of environmental management. The first error has been an implicit assumption that ecosystem responses to human use are linear, predictable and controllable. The second has been an assumption that human and natural systems can be treated independently. However, evidence that has been accumulating in diverse regions all over the world suggests that natural and social systems behave in nonlinear ways, exhibit marked thresholds in their dynamics, and that social-ecological systems act as strongly coupled, complex and evolving integrated systems. This article is a summary of a report prepared on behalf of the Environmental Advisory Council to the Swedish Government, as input to the process of the World Summit on Sustainable Development (WSSD) in Johannesburg, South Africa in 26 August 4 September 2002. We use the concept of resilience—the capacity to buffer change, learn and develop—as a framework for understanding how to sustain and enhance adaptive capacity in a complex world of rapid transformations. Two useful tools for resilience-building in social-ecological systems are structured scenarios and active adaptive management. These tools require and facilitate a social context with flexible and open institutions and multi-level governance systems that allow for learning and increase adaptive capacity without foreclosing future development options.

https://bioone.org/journals/AMBIO-A-Journal-of-the-Human-Environment/volume-31/issue-5/0044-7447-31.5.437/Resilience-and-Sustainable-Development--Building-Adaptive-Capacity-in-a/10.1579/0044-7447-31.5.437.pdf

Resilience and sustainable development: building adaptive capacity in a world of transformations

Major features of contemporary forest governance include decentralization of forest management, logging concessions in publicly owned commercially valuable forests, and timber certification, primarily in temperate forests. Although a majority of forests continue to be owned formally by governments, the effectiveness of forest governance is increasingly independent of formal ownership. Growing and competing demands for food, biofuels, timber, and environmental services will pose severe challenges to effective forest governance in the future, especially in conjunction with the direct and indirect impacts of climate change. A greater role for community and market actors in forest governance and deeper attention to the factors that lead to effective governance, beyond ownership patterns, is necessary to address future forest governance challenges.

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Changing Governance of the World's Forests

Forests provide multiple benefits at local to global scales. These include the global public good of carbon sequestration and local and national level contributions to livelihoods for more than half a billion users. Forest commons are a particularly important class of forests generating these multiple benefits. Institutional arrangements to govern forest commons are believed to substantially influence carbon storage and livelihood contributions, especially when they incorporate local knowledge and decentralized decision making. However, hypothesized relationships between institutional factors and multiple benefits have never been tested on data from multiple countries. By using original data on 80 forest commons in 10 countries across Asia, Africa, and Latin America, we show that larger forest size and greater rule-making autonomy at the local level are associated with high carbon storage and livelihood benefits; differences in ownership of forest commons are associated with trade-offs between livelihood benefits and carbon storage. We argue that local communities restrict their consumption of forest products when they own forest commons, thereby increasing carbon storage. In showing rule-making autonomy and ownership as distinct and important institutional influences on forest outcomes, our results are directly relevant to international climate change mitigation initiatives such as Reduced Emissions from Deforestation and Forest Degradation (REDD) and avoided deforestation. Transfer of ownership over larger forest commons patches to local communities, coupled with payments for improved carbon storage can contribute to climate change mitigation without adversely affecting local livelihoods.

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Trade-offs and synergies between carbon storage and livelihood benefits from forest commons

Causal pathways to achieve social and ecological benefits from forests are unclear, because there are few systematic multicountry empirical analyses that identify important factors and their complex relationships with social and ecological outcomes. This study examines biodiversity conservation and forest-based livelihood outcomes using a data set on 84 sites from six countries in East Africa and South Asia. We find both positive and negative relationships, leading to joint wins, losses, and trade-offs depending on specific contextual factors; participation in forest governance institutions by local forest users is strongly associated with jointly positive outcomes for forests in our study.

https://science.sciencemag.org/content/sci/331/6024/1606.full.pdf

Social and Ecological Synergy: Local Rulemaking, Forest Livelihoods, and Biodiversity Conservation

https://www.eastwestcenter.org/sites/default/files/filemanager/Research_Program/NSFNepal/2006._Arun_Agrawal_and_Ashwini_Chhatre._Explainaing_Success_on_the_Commons.pdf

Explaining success on the commons: Community forest governance in the Indian Himalaya

Reducing emissions from deforestation and forest degradation (REDD+) policies, projects, and interventions are among the most prominent of recent attempts to mitigate climate change. Because REDD+ projects focus on forests, they simultaneously affect socioeconomic and ecological outcomes at local, subnational, national, regional, and global levels. This review assesses the promise of REDD+ for the continued ability of forests to provide multiple benefits to human societies at multiple scales. We survey REDD+ efforts at different levels, examining them through an actor-oriented approach. The article highlights the criticality of collaborative action to enhance desired outcomes of REDD+ efforts. In summarizing major REDD+ future trends, the paper emphasizes the need to learn from past forestry, agricultural, biodiversity, and development policies, and for adaptive policy making.

https://www.annualreviews.org/doi/pdf/10.1146/annurev-environ-042009-094508

Ashwini Chhatre

Papers

Changing Governance of the World's Forests

Trade-offs and synergies between carbon storage and livelihood benefits from forest commons

Social and Ecological Synergy: Local Rulemaking, Forest Livelihoods, and Biodiversity Conservation

Explaining success on the commons: Community forest governance in the Indian Himalaya

Reducing Emissions from Deforestation and Forest Degradation