Astrid M. Roy-Engel

TL;DR: Tests of the senescence-associated β-galactosidase expression suggest that expression of exogenous full-length L1, or the SpORF2 mRNA alone in human fibroblasts and adult stem cells triggers a senescENCE-like phenotype, which is one of the reported responses to DNA damage.

TL;DR: Analysis of mosaic Yb8 elements suggests gene conversion played an important role in generating sequence diversity among these elements, and newly identified Alu insertion polymorphisms will be useful tools for the study of human genomic diversity.

TL;DR: This review is focused on the cellular mechanisms that control human TE-associated mutagenesis in cancer and summarizes the current understanding of TE contribution to genetic instability in human malignancies.

TL;DR: Three previously classified Alu Y elements linked with disease belong to the Yc1 subfamily, supporting the retroposition potential of this subfamily and demonstrating that the AluY subfamily currently has a very low amplification rate in the human genome.

TL;DR: The data presented in this paper indicate that the length of Alu "A-tails" is one of the principal factors in determining the retropositional capability of an Alu element.