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Atahualpa Castillo Morales
Researcher at University of Bath
Publications - 6
Citations - 217
Atahualpa Castillo Morales is an academic researcher from University of Bath. The author has contributed to research in topics: Codon usage bias & Synonymous substitution. The author has an hindex of 4, co-authored 6 publications receiving 131 citations.
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Journal ArticleDOI
Conditional expression explains molecular evolution of social genes in a microbe
Janaina Lima de Oliveira,Atahualpa Castillo Morales,Balint Stewart,Nicole Gruenheit,Jennifer Engelmoer,Suzanne Battom Brown,Reinaldo Alves de Brito,Laurence D. Hurst,Araxi O. Urrutia,Araxi O. Urrutia,Christopher R. L. Thompson,Jason B. Wolf +11 more
TL;DR: In Dictyostelium discoideum, social genes in fact exhibit diversification patterns consistent with relaxed purifying selection, likely due to their expression only in intermittent social generations, which the authors call the Red King process.
Journal ArticleDOI
Evidence for strong mutation bias towards, and selection against, U content in SARS-CoV-2: implications for vaccine design.
Alan M. Rice,Atahualpa Castillo Morales,Alexander T Ho,Christine Mordstein,Christine Mordstein,Stephanie Mühlhausen,Semir Watson,Laura Cano,Bethan Young,Bethan Young,Grzegorz Kudla,Laurence D. Hurst +11 more
TL;DR: An evolutionarily informed approach to attenuation is proposed that, unusually, seeks to increase usage of the already most common synonymous codons in SARS-CoV-2 genes.
Journal ArticleDOI
Causes and consequences of purifying selection on SARS-CoV-2.
Atahualpa Castillo Morales,Alan M. Rice,Alexander T Ho,Christine Mordstein,Christine Mordstein,Christine Mordstein,Stefanie Mühlhausen,Samir F Watson,Laura Cano,Bethan Young,Bethan Young,Grzegorz Kudla,Laurence D. Hurst +12 more
TL;DR: In this article, it was shown that the SARS-CoV-2 mutation rate is at least 49-67% higher than would be estimated based on the rate of appearance of variants in sampled genomes.
Journal ArticleDOI
Transcription, mRNA export and immune evasion shape the codon usage of viruses
Christine Mordstein,Laura Cano,Atahualpa Castillo Morales,Bethan Young,Bethan Young,Alexander T Ho,Alan M. Rice,Michael Liss,Laurence D. Hurst,Grzegorz Kudla +9 more
TL;DR: This paper analyzed the patterns of codon usage in 1,520 vertebrate-infecting viruses, focusing on parameters known to be under selection and associated with gene regulation, and found that GC content, dinucleotide content, and splicing and m6A modification-related sequence motifs are associated with the type of genetic material (DNA or RNA), strandedness, and replication compartment of viruses.
Posted ContentDOI
Evidence for strong mutation bias towards, and selection against, T/U content in SARS-CoV2: implications for attenuated vaccine design.
Alan M. Rice,Atahualpa Castillo Morales,Alexander T Ho,Christine Mordstein,Christine Mordstein,Stefanie Mühlhausen,Samir F Watson,Laura Cano,Bethan Young,Bethan Young,Grzegorz Kudla,Laurence D. Hurst +11 more
TL;DR: An evolutionarily informed gene-bespoke approach to attenuation that, unusually, seeks to increase usage of the already most common synonymous codons in relation to SARS-CoV2 genes.