[신간의 별자리x] 우리/미술, 그리고 ‘슬픔의 박물관’

As a subfield of machine learning, reinforcement learning (RL) aims at empowering one's capabilities in behavioural decision making by using interaction experience with the world and an evaluative feedback. Unlike traditional supervised learning methods that usually rely on one-shot, exhaustive and supervised reward signals, RL tackles with sequential decision making problems with sampled, evaluative and delayed feedback simultaneously. Such distinctive features make RL technique a suitable candidate for developing powerful solutions in a variety of healthcare domains, where diagnosing decisions or treatment regimes are usually characterized by a prolonged and sequential procedure. This survey discusses the broad applications of RL techniques in healthcare domains, in order to provide the research community with systematic understanding of theoretical foundations, enabling methods and techniques, existing challenges, and new insights of this emerging paradigm. By first briefly examining theoretical foundations and key techniques in RL research from efficient and representational directions, we then provide an overview of RL applications in healthcare domains ranging from dynamic treatment regimes in chronic diseases and critical care, automated medical diagnosis from both unstructured and structured clinical data, as well as many other control or scheduling domains that have infiltrated many aspects of a healthcare system. Finally, we summarize the challenges and open issues in current research, and point out some potential solutions and directions for future research.

Reinforcement Learning in Healthcare: A Survey

Reinforcement Learning (RL) is a key technique to address sequential decision-making problems and is crucial to realize advanced artificial intelligence. Recent years have witnessed remarkable progress in RL by virtue of the fast development of deep neural networks. Along with the promising prospects of RL in numerous domains, such as robotics and game-playing, transfer learning has arisen as an important technique to tackle various challenges faced by RL, by transferring knowledge from external expertise to accelerate the learning process. In this survey, we systematically investigate the recent progress of transfer learning approaches in the context of deep reinforcement learning. Specifically, we provide a framework for categorizing the state-of-the-art transfer learning approaches, under which we analyze their goals, methodologies, compatible RL backbones, and practical applications. We also draw connections between transfer learning and other relevant topics from the RL perspective and explore their potential challenges as well as open questions that await future research progress.

Transfer Learning in Deep Reinforcement Learning: A Survey

Medical image analysis is currently experiencing a paradigm shift due to deep learning. This technology has recently attracted so much interest of the Medical Imaging Community that it led to a specialized conference in “Medical Imaging with Deep Learning” in the year 2018. This paper surveys the recent developments in this direction and provides a critical review of the related major aspects. We organize the reviewed literature according to the underlying pattern recognition tasks and further sub-categorize it following a taxonomy based on human anatomy. This paper does not assume prior knowledge of deep learning and makes a significant contribution in explaining the core deep learning concepts to the non-experts in the Medical Community. This paper provides a unique computer vision/machine learning perspective taken on the advances of deep learning in medical imaging. This enables us to single out “lack of appropriately annotated large-scale data sets” as the core challenge (among other challenges) in this research direction. We draw on the insights from the sister research fields of computer vision, pattern recognition, and machine learning, where the techniques of dealing with such challenges have already matured, to provide promising directions for the Medical Imaging Community to fully harness deep learning in the future.

Going Deep in Medical Image Analysis: Concepts, Methods, Challenges, and Future Directions

Machine learning (ML) is making a dramatic impact on cardiovascular magnetic resonance (CMR) in many ways. This review seeks to highlight the major areas in CMR where ML, and deep learning in particular, can assist clinicians and engineers in improving imaging efficiency, quality, image analysis and interpretation, as well as patient evaluation. We discuss recent developments in the field of ML relevant to CMR in the areas of image acquisition & reconstruction, image analysis, diagnostic evaluation and derivation of prognostic information. To date, the main impact of ML in CMR has been to significantly reduce the time required for image segmentation and analysis. Accurate and reproducible fully automated quantification of left and right ventricular mass and volume is now available in commercial products. Active research areas include reduction of image acquisition and reconstruction time, improving spatial and temporal resolution, and analysis of perfusion and myocardial mapping. Although large cohort studies are providing valuable data sets for ML training, care must be taken in extending applications to specific patient groups. Since ML algorithms can fail in unpredictable ways, it is important to mitigate this by open source publication of computational processes and datasets. Furthermore, controlled trials are needed to evaluate methods across multiple centers and patient groups.

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Machine learning in cardiovascular magnetic resonance: basic concepts and applications

Evaluating reinforcement learning agents for anatomical landmark detection.

The detection of anatomical landmarks is a vital step for medical image analysis and applications for diagnosis, interpretation and guidance. Manual annotation of landmarks is a tedious process that requires domain-specific expertise and introduces inter-observer variability. This paper proposes a new detection approach for multiple landmarks based on multi-agent reinforcement learning. Our hypothesis is that the position of all anatomical landmarks is interdependent and non-random within the human anatomy, thus finding one landmark can help to deduce the location of others. Using a Deep Q-Network (DQN) architecture we construct an environment and agent with implicit inter-communication such that we can accommodate K agents acting and learning simultaneously, while they attempt to detect K different landmarks. During training the agents collaborate by sharing their accumulated knowledge for a collective gain. We compare our approach with state-of-the-art architectures and achieve significantly better accuracy by reducing the detection error by \(50\%\), while requiring fewer computational resources and time to train compared to the naive approach of training K agents separately. Code and visualizations available: https://github.com/thanosvlo/MARL-for-Anatomical-Landmark-Detection

Multiple Landmark Detection Using Multi-agent Reinforcement Learning

The detection of anatomical landmarks is a vital step for medical image analysis and applications for diagnosis, interpretation and guidance. Manual annotation of landmarks is a tedious process that requires domain-specific expertise and introduces inter-observer variability. This paper proposes a new detection approach for multiple landmarks based on multi-agent reinforcement learning. Our hypothesis is that the position of all anatomical landmarks is interdependent and non-random within the human anatomy, thus finding one landmark can help to deduce the location of others. Using a Deep Q-Network (DQN) architecture we construct an environment and agent with implicit inter-communication such that we can accommodate K agents acting and learning simultaneously, while they attempt to detect K different landmarks. During training the agents collaborate by sharing their accumulated knowledge for a collective gain. We compare our approach with state-of-the-art architectures and achieve significantly better accuracy by reducing the detection error by 50%, while requiring fewer computational resources and time to train compared to the naive approach of training K agents separately.

Multiple Landmark Detection using Multi-Agent Reinforcement Learning

Human pose estimation is a major computer vision problem with applications ranging from augmented reality and video capture to surveillance and movement tracking. In the medical context, the latter may be an important biomarker for neurological impairments in infants. Whilst many methods exist, their application has been limited by the need for well annotated large datasets and the inability to gen-eralize to humans of different shapes and body compositions, e.g. children and infants. In this paper we present a novel method for learning pose estimators for human adults and infants in an unsupervised fashion. We approach this as a learnable template matching problem facilitated by deep feature extractors. Human-interpretable landmarks are estimated by transforming a template consisting of predefined body parts that are characterized by 2D Gaussian distributions. Enforcing a connectivity prior guides our model to meaningful human shape representations. We demonstrate the effectiveness of our approach on two different datasets including adults and infants. Project page: infantmotion.github.io

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Unsupervised Human Pose Estimation through Transforming Shape Templates

Video is an essential imaging modality for diagnostics, e.g. in ultrasound imaging, for endoscopy, or movement assessment. However, video hasn’t received a lot of attention in the medical image analysis community. In the clinical practice, it is challenging to utilise raw diagnostic video data efficiently as video data takes a long time to process, annotate or audit. In this paper we introduce a novel, fully automatic video summarization method that is tailored to the needs of medical video data. Our approach is framed as reinforcement learning problem and produces agents focusing on the preservation of important diagnostic information. We evaluate our method on videos from fetal ultrasound screening, where commonly only a small amount of the recorded data is used diagnostically. We show that our method is superior to alternative video summarization methods and that it preserves essential information required by clinical diagnostic standards.

Athanasios Vlontzos

Papers

Evaluating reinforcement learning agents for anatomical landmark detection.

Multiple Landmark Detection Using Multi-agent Reinforcement Learning

Multiple Landmark Detection using Multi-Agent Reinforcement Learning

Unsupervised Human Pose Estimation through Transforming Shape Templates

Ultrasound Video Summarization using Deep Reinforcement Learning