A
Atsushi Ogata
Researcher at Osaka University
Publications - 173
Citations - 7403
Atsushi Ogata is an academic researcher from Osaka University. The author has contributed to research in topics: Tocilizumab & Rheumatoid arthritis. The author has an hindex of 48, co-authored 173 publications receiving 6840 citations. Previous affiliations of Atsushi Ogata include Singapore General Hospital & University of Tsukuba.
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Journal Article
IL-6 triggers cell growth via the Ras-dependent mitogen-activated protein kinase cascade.
Atsushi Ogata,Dharminder Chauhan,Gerrard Teoh,Steven P. Treon,Mitsuyoshi Urashima,Robert L. Schlossman,KC Anderson +6 more
TL;DR: The data suggest that STAT1 and/or STAT3 activation may occur independently of the proliferative response to IL-6, and that activation of the MAPK cascade is an important distal pathway for IL- 6-mediated growth.
Journal Article
Interleukin-6 as a new indicator of inflammatory status: detection of serum levels of interleukin-6 and C-reactive protein after surgery.
Hiroki Ohzato,Kazuyuki Yoshizaki,N Nishimoto,Atsushi Ogata,Hiromi Tagoh,Morito Monden,Mitsukazu Gotoh,Tadamitsu Kishimoto,Mori T +8 more
TL;DR: The findings indicate that the increase in IL-6 triggered by a surgical procedure may function as a hepatocyte-stimulating factor and that monitoring of SIL-6 may be more helpful than monitoring of SCRP for estimation of inflammatory status and early detection of an acute-phase response.
Journal ArticleDOI
Flavonoids and Related Compounds as Anti-Allergic Substances
Mari Kawai,Toru Hirano,Shinji Higa,Junsuke Arimitsu,Michiru Maruta,Yusuke Kuwahara,Tomoharu Ohkawara,Keisuke Hagihara,Tomoki Yamadori,Yoshihito Shima,Atsushi Ogata,Ichiro Kawase,Toshio Tanaka +12 more
TL;DR: It is expected that a dietary menu including an appropriate intake of flavonoids may provide a form of complementary and alternative medicine and a preventative strategy for allergic diseases.
Journal ArticleDOI
Hypoxic stress induces cardiac myocyte-derived interleukin-6
Keiko Yamauchi-Takihara,Yoshiji Ihara,Atsushi Ogata,Kazuyuki Yoshizaki,Junichi Azuma,Tadamitsu Kishimoto +5 more
TL;DR: Cardiac myocytes respond to hypoxic stress to augment the production of IL-6, and theIL-6 derived from cardiac myocytes may play an important role in the progression of myocardial dysfunction observed in cardiac ischemia-reperfusion injury.
Journal ArticleDOI
Interleukin-6 Inhibits Fas-Induced Apoptosis and Stress-Activated Protein Kinase Activation in Multiple Myeloma Cells
Dharminder Chauhan,Surender Kharbanda,Atsushi Ogata,Mitsuyoshi Urashima,Gerrard Teoh,Michael J. Robertson,Donald Kufe,Kenneth C. Anderson +7 more
TL;DR: It is suggested that anti-Fas MoAb-induced apoptosis in MM cells is associated with activation of SAPK, and that IL-6 may both inhibit apoptosis and modulate SAPK activity.