A
Atsushi Takahashi
Researcher at Osaka University
Publications - 27
Citations - 2434
Atsushi Takahashi is an academic researcher from Osaka University. The author has contributed to research in topics: Autophagy & Cellular homeostasis. The author has an hindex of 17, co-authored 27 publications receiving 1835 citations.
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Chloroquine in cancer therapy: a double-edged sword of autophagy.
TL;DR: The functions of autophagy in cancer and kidney injury are summarized, especially focusing on the use of chloroquine to treat cancer, and the possible side effects are addressed in the combined use ofchloroquine and anticancer drugs.
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Autophagy sequesters damaged lysosomes to control lysosomal biogenesis and kidney injury
Ikuko Maejima,Atsushi Takahashi,Hiroko Omori,Tomonori Kimura,Yoshitsugu Takabatake,Tatsuya Saitoh,Akitsugu Yamamoto,Maho Hamasaki,Takeshi Noda,Yoshitaka Isaka,Tamotsu Yoshimori +10 more
TL;DR: It is demonstrated that lysosomes are selectively sequestered by autophagy, when damaged by MSU, silica, or the lysOSomotropic reagent L‐Leucyl‐L‐leucine methyl ester (LLOMe).
Journal ArticleDOI
Autophagy protects the proximal tubule from degeneration and acute ischemic injury.
Tomonori Kimura,Yoshitsugu Takabatake,Atsushi Takahashi,Jun-ya Kaimori,Isao Matsui,Tomoko Namba,Harumi Kitamura,Fumio Niimura,Taiji Matsusaka,Tomoyoshi Soga,Hiromi Rakugi,Yoshitaka Isaka +11 more
TL;DR: The data suggest that autophagy maintains proximal tubule cell homeostasis and protects against ischemic injury, and may provide a novel therapeutic approach to minimize acute kidney injury and slow CKD progression.
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Autophagy guards against cisplatin-induced acute kidney injury.
Atsushi Takahashi,Tomonori Kimura,Yoshitsugu Takabatake,Tomoko Namba,Jun-ya Kaimori,Harumi Kitamura,Isao Matsui,Fumio Niimura,Taiji Matsusaka,Naonobu Fujita,Tamotsu Yoshimori,Yoshitaka Isaka,Hiromi Rakugi +12 more
TL;DR: The hypothesis that autophagy guards against acute kidney injury (AKI) by modulating several deteriorative pathways that lead to tubular cell death using a cisplatin-induced model of AKI is examined.
Journal ArticleDOI
Suppression of autophagic activity by Rubicon is a signature of aging.
Shuhei Nakamura,Masaki Oba,Mari Suzuki,Atsushi Takahashi,Tadashi Yamamuro,Mari Fujiwara,Kensuke Ikenaka,Satoshi Minami,Namine Tabata,Kenichi Yamamoto,Sayaka Kubo,Ayaka Tokumura,Kanako Akamatsu,Yumi Miyazaki,Tsuyoshi Kawabata,Tsuyoshi Kawabata,Maho Hamasaki,Koji Fukui,Kazunori Sango,Yoshihisa Watanabe,Yoshitsugu Takabatake,Tomoya S. Kitajima,Tomoya S. Kitajima,Yukinori Okada,Hideki Mochizuki,Yoshitaka Isaka,Adam Antebi,Tamotsu Yoshimori +27 more
TL;DR: In this paper, the expression of Rubicon, a negative regulator of autophagy, increases in aged worm, fly and mouse tissues at transcript and/or protein levels, suggesting that an age-dependent increase in Rubicon impairs autophag over time, and thereby curtails animal healthspan.