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Atsutoshi Yoshimura
Researcher at Nagasaki University
Publications - 58
Citations - 2893
Atsutoshi Yoshimura is an academic researcher from Nagasaki University. The author has contributed to research in topics: Porphyromonas gingivalis & Aggregatibacter actinomycetemcomitans. The author has an hindex of 23, co-authored 58 publications receiving 2682 citations.
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Journal ArticleDOI
Toll-like receptor 4 imparts ligand-specific recognition of bacterial lipopolysaccharide
Egil Lien,Terry K. Means,Holger Heine,Atsutoshi Yoshimura,Shoichi Kusumoto,Koichi Fukase,Matthew J. Fenton,Masato Oikawa,Nilofer Qureshi,Brian G. Monks,Robert W. Finberg,Robin R. Ingalls,Douglas T. Golenbock +12 more
TL;DR: Data suggest that TLR4 is the central lipid A-recognition protein in the LPS receptor complex, which is likely to be responsible for the species-specific pharmacology of LPS.
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Molecular Genetic Analysis of an Endotoxin Nonresponder Mutant Cell Line A Point Mutation in a Conserved Region of Md-2 Abolishes Endotoxin-Induced Signaling
Andra B. Schromm,Egil Lien,Philipp Henneke,Jesse Chow,Atsutoshi Yoshimura,Holger Heine,Eicke Latz,Brian G. Monks,David A. Schwartz,Kensuke Miyake,Douglas T. Golenbock +10 more
TL;DR: MD-2 is a required component of the LPS signaling complex and can function as a soluble receptor for cells that do not otherwise express it, and it is hypothesize that MD-2 conformationally affects the extracellular domain of TLR4, perhaps resulting in a change in affinity for LPS or functioning as a portion of the true ligand forTLR4.
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Relationship between Structures and Biological Activities of Mycoplasmal Diacylated Lipopeptides and Their Recognition by Toll-Like Receptors 2 and 6
Tsugumi Okusawa,Mari Fujita,Jun Ichiro Nakamura,Takeshi Into,Motoaki Yasuda,Atsutoshi Yoshimura,Yoshitaka Hara,Akira Hasebe,Douglas T. Golenbock,Manabu Morita,Yoshio Kuroki,Tomohiko Ogawa,Ken-ichiro Shibata +12 more
TL;DR: Both the diacylglyceryl and the peptide portions of F SL-1 are indispensable for the expression of biological activities and for the recognition by Toll-like receptors 2 and 6 and that the recognition of FSL-1 by Toll -like receptors2 and 6 appears to be hydrophobic.
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Lipopolysaccharides from Periodontopathic Bacteria Porphyromonas gingivalis and Capnocytophaga ochracea Are Antagonists for Human Toll-Like Receptor 4
TL;DR: Findings indicated that LPS from P. gingivalis and C. ochracea worked as antagonists for human TLR4, which may be associated with the etiology of periodontal diseases.
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Secretion of IL-1 beta, TNF-alpha, IL-8 and IL-1ra by human polymorphonuclear leukocytes in response to lipopolysaccharides from periodontopathic bacteria.
TL;DR: It is demonstrated that LPS from periodontopathic bacteria were capable of stimulating PMN to release not only pro-inflammatory cytokines but also their inhibitors such as IL-1ra, which might be important in the onset and progression of periodontal diseases.