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Aubrey Harding

Bio: Aubrey Harding is an academic researcher from National College of Natural Medicine. The author has contributed to research in topics: Prevalence & Depression (differential diagnoses). The author has an hindex of 1, co-authored 1 publications receiving 218 citations.

Papers
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Journal ArticleDOI
TL;DR: Results from this systematic review indicate that patients with IBD have about a 20% prevalence rate of anxiety and a 15% prevalence rates of depression.

361 citations


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Journal ArticleDOI
TL;DR: A systematic review and meta-analysis of Randomised controlled trials recruiting patients with inflammatory bowel disease aged at least 16 years that compared psychological therapy with a control intervention or usual treatment found no effect on disease activity indices or other psychological wellbeing scores when compared with control.

204 citations

Journal ArticleDOI
20 Aug 2020
TL;DR: The epidemiology, mechanisms, diagnosis and treatment of comorbid depression in patients with medical diseases, including major depressive disorder, are discussed.
Abstract: Depression is one of the most common comorbidities of many chronic medical diseases including cancer and cardiovascular, metabolic, inflammatory and neurological disorders. Indeed, the prevalence of depression in these patient groups is often substantially higher than in the general population, and depression accounts for a substantial part of the psychosocial burden of these disorders. Many factors can contribute to the occurrence of comorbid depression, such as shared genetic factors, converging biological pathways, social factors, health behaviours and psychological factors. Diagnosis of depression in patients with a medical disorder can be particularly challenging owing to symptomatic overlap. Although pharmacological and psychological treatments can be effective, adjustments may need to be made for patients with a comorbid medical disorder. In addition, symptoms or treatments of medical disorders may interfere with the treatment of depression. Conversely, symptoms of depression may decrease adherence to treatment of both disorders. Thus, comprehensive treatment plans are necessary to optimize care.

191 citations

Journal ArticleDOI
TL;DR: This review aims to summarize recent advances in epithelial transport and barrier function and to highlight how bile acids are now emerging as exciting new targets for disease intervention.
Abstract: Epithelial cells line the entire surface of the gastrointestinal tract and its accessory organs where they primarily function in transporting digestive enzymes, nutrients, electrolytes, and fluid t...

169 citations

Journal ArticleDOI
TL;DR: In this paper, a systematic review and meta-analysis was conducted to assess prevalence of symptoms of anxiety or depression in adult patients with inflammatory bowel disease (IBD) and found that up to a third of patients affected by anxiety symptoms and a quarter affected by depression symptoms.

163 citations

Journal ArticleDOI
TL;DR: Observational data suggest that the effect of disordered brain-gut axis activity in IBD is substantial, and scope remains for further well designed trials of psychological therapies and antidepressants, particularly in the subset of patients who have coexistent psychological disorders, or in those who report IBS-type symptoms.

150 citations