Audray K. Harris

TL;DR: Vaccination of mice and ferrets with H1–SS–np elicited broadly cross-reactive antibodies that completely protected mice and partially protected ferrets against lethal heterosubtypic H5N1 influenza virus challenge despite the absence of detectable H 5N1 neutralizing activity in vitro.

TL;DR: Cryoelectron tomography is used to visualize the 3D structures of 110 individual virions of the X-31 (H3N2) strain of influenza A, and some virions have substantial gaps in their matrix layer, and others appear to lack a matrix layer entirely, suggesting the existence of an alternative budding pathway in which matrix protein is minimally involved.

TL;DR: It is found that vaccination with DNA expressing the premembrane and envelope proteins of ZIKV was immunogenic in mice and nonhuman primates, and protection against viremia after ZikV challenge correlated with serum neutralizing activity.

TL;DR: A mosaic nanoparticle vaccine against influenza virus that is able to elicit neutralizing antibodies that span nearly 100 years of variation of influenza A virus is developed.

TL;DR: It is demonstrated that soluble gp140 trimers can be designed to mimic the quaternary structural transitions displayed by native trimeric Env on the surface of intact HIV-1 virions.