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Aurora Esquela-Kerscher
Researcher at Eastern Virginia Medical School
Publications - 23
Citations - 14997
Aurora Esquela-Kerscher is an academic researcher from Eastern Virginia Medical School. The author has contributed to research in topics: microRNA & Gene silencing. The author has an hindex of 12, co-authored 21 publications receiving 14503 citations. Previous affiliations of Aurora Esquela-Kerscher include Yale University.
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Journal Article
Oncomirs : microRNAs with a role in cancer
TL;DR: I MicroRNAs (miRNAs) are an abundant class of small non-protein-coding RNAs that function as negative gene regulators as discussed by the authors, and have been shown to repress the expression of important cancer-related genes and might prove useful in the diagnosis and treatment of cancer.
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Oncomirs — microRNAs with a role in cancer
TL;DR: Evidence has shown that miRNA mutations or mis-expression correlate with various human cancers and indicates that miRNAs can function as tumour suppressors and oncogenes.
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The let-7 MicroRNA represses cell proliferation pathways in human cells
Charles D. Johnson,Aurora Esquela-Kerscher,Giovanni Stefani,Mike Byrom,Kevin Kelnar,Dmitriy Ovcharenko,Michael R. Wilson,Xiaowei Wang,Jeffrey Shelton,Jaclyn Shingara,Lena Chin,David F.M. Brown,Frank J. Slack +12 more
TL;DR: This work reveals the let-7 microRNA to be a master regulator of cell proliferation pathways and shows that multiple genes involved in cell cycle and cell division functions are also directly or indirectly repressed byLet-7.
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The let-7 microRNA reduces tumor growth in mouse models of lung cancer.
Aurora Esquela-Kerscher,Phong Trang,Jason F. Wiggins,Lubna Patrawala,Angie Cheng,Lance P. Ford,Joanne B. Weidhaas,David F.M. Brown,Andreas G. Bader,Frank J. Slack +9 more
TL;DR: In this paper, the authors used both in vitro and in vivo approaches to show that the let-7 microRNA directly represses cancer growth in the lung and indicated that this miRNA may be useful as a novel therapeutic agent in lung cancer.
Journal Article
The let-7 microrna reduces tumor growth in mouse models of lung cancer
Aurora Esquela-Kerscher,Phong Trang,Lance Ford,David Brown,Joanne B. Weidhaas,Frank J. Slack +5 more
TL;DR: Findings provide direct evidence that let-7 acts as a tumor suppressor gene in the lung and indicate that this miRNA may be useful as a novel therapeutic agent in lung cancer.