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Austin L. Gurney
Researcher at Genentech
Publications - 463
Citations - 18847
Austin L. Gurney is an academic researcher from Genentech. The author has contributed to research in topics: Nucleic acid & Nucleic acid methods. The author has an hindex of 45, co-authored 463 publications receiving 18357 citations.
Papers
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Journal ArticleDOI
Interleukin-23 Promotes a Distinct CD4 T Cell Activation State Characterized by the Production of Interleukin-17
TL;DR: Evidence is presented that murine IL-23, which is produced by activated dendritic cells, acts on memory T cells, resulting in elevated IL-17 secretion, which suggests that during a secondary immune response, IL- 23 can promote an activation state with features distinct from the well characterized Th1 and Th2 profiles.
Journal ArticleDOI
Control of TRAIL-Induced Apoptosis by a Family of Signaling and Decoy Receptors
James P. Sheridan,Scot A. Marsters,Robert M. Pitti,Austin L. Gurney,Maya Skubatch,Daryl T. Baldwin,Lakshmi Ramakrishnan,Christa L. Gray,Kevin P. Baker,William I. Wood,Audrey Goddard,Paul J. Godowski,Avi Ashkenazi +12 more
TL;DR: A cell surface mechanism exists for the regulation of cellular responsiveness to pro-apoptotic stimuli in tumor cells.
Journal ArticleDOI
Stimulation of megakaryocytopoiesis and thrombopoiesis by the c-Mpl ligand
Frederic J. de Sauvage,Philip E. Hass,Susan D. Spencer,Beth E. Malloy,Austin L. Gurney,Steven A. Spencer,Walter C. Darbonne,William J. Henzel,Suzy C. Wong,Wun-Jing Kuang,Karl J. Oles,Bruce Hultgren,Lawrence A. Solberg,David V. Goeddel,Dan L. Eaton +14 more
TL;DR: A meg-CSF/thrombopoietin-like protein that is present in plasma of irradiated pigs has been purified and cloned and binds to and activates the c-mpl protein, a member of the cytokine receptor superfamily.
Patent
Secreted and Transmembrane Polypeptides and Nucleic Acids Encoding the Same
Kevin P. Baker,Maureen Beresini,Laura DeForge,Luc Desnoyers,Ellen Filvaroff,Wei-Qiang Gao,Mary E. Gerritsen,Audrey Goddard,Paul J. Godowski,Austin L. Gurney,Steven Sherwood,Victoria Smith,Timothy A. Stewart,Daniel Tumas,Colin K. Watanabe,William I. Wood,Zemin Zhang +16 more
TL;DR: In this paper, the present invention is directed to secreted and transmembrane polypeptides and to nucleic acid molecules encoding those polyptides, and vectors and host cells comprising those nucleic amino acid sequences.
Journal ArticleDOI
Toll-like receptor-2 mediates lipopolysaccharide-induced cellular signalling
Ruey-Bing Yang,Melanie R. Mark,Alane M. Gray,Arthur J Huang,Ming Hong Xie,Min Zhang,Audrey Goddard,William I. Wood,Austin L. Gurney,Paul J. Godowski +9 more
TL;DR: It is shown that Toll-like receptor 2 (TLR2) is a signalling receptor that is activated by LPS in a response that depends on LPS-binding protein and is enhanced by CD14, and that TLR2 is a direct mediator of signalling by L PS.