A
Avraham Raz
Researcher at Wayne State University
Publications - 210
Citations - 18098
Avraham Raz is an academic researcher from Wayne State University. The author has contributed to research in topics: Autocrine Motility Factor & Cancer. The author has an hindex of 76, co-authored 206 publications receiving 17055 citations. Previous affiliations of Avraham Raz include Montana State University & Osaka University.
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Galectins: a family of animal beta-galactoside-binding lectins.
Samuel H. Barondes,Vincent Castronovo,Douglas N.W. Cooper,Richard D. Cummings,Kurt Drickamer,Ten Felzi,Michael A. Gitt,Jun Hirabayashi,Colin Hughes,Ken-ichi Kasai,Hakon Leffler,Fu-Tong Liu,Reuben Lotan,Arthur M. Mercurio,Michel Monsigny,Shiv Pillai,Françoise Poirer,Avraham Raz,Peter W.J. Rigby,James M. Rini,John L. Wang +20 more
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Murine models to evaluate novel and conventional therapeutic strategies for cancer.
TL;DR: It is recommended that future studies incorporate orthotopic and spontaneous metastasis models (syngeneic and xenogenic) because they incorporate microenvironmental interactions, in addition to confirmatory autochthonous models and/or genetically engineered models, for molecular therapeutics.
Journal Article
Galectin-3: A novel antiapoptotic molecule with a functional BH1 (NWGR) domain of Bcl-2 family
TL;DR: It is demonstrated that expression of galectin-3 in human breast carcinoma BT549 cells inhibits cis-diamminedichloroplatinum (cisplatin)-induced poly(ADP-ribose) polymerase degradation and apoptosis, without altering B cl-2, Bcl-X(L), or Bax expressions.
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Galectin-3 Induces Endothelial Cell Morphogenesis and Angiogenesis
Pratima Nangia-Makker,Yuichiro Honjo,Rebecca Sarvis,Shiro Akahani,Victor Hogan,Kenneth J. Pienta,Avraham Raz +6 more
TL;DR: It is demonstrated that endothelial cell surface carbohydrate recognition event(s) can induce a signaling cascade leading to the differentiation and angiogenesis of endothelial cells.
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Inhibition of Human Cancer Cell Growth and Metastasis in Nude Mice by Oral Intake of Modified Citrus Pectin
Pratima Nangia-Makker,Victor Hogan,Yuichiro Honjo,Yuichiro Honjo,Sara Baccarini,Larry Tait,Robert S. Bresalier,Avraham Raz +7 more
TL;DR: Tumor growth, angiogenesis, and spontaneous metastasis in vivo were statistically significantly reduced in mice fed MCP, presumably via its effects on galectin-3 function, and the importance of dietary carbohydrate compounds as agents for the prevention and/or treatment of cancer is stressed.