Ayako Miura

TL;DR: The replication-defective adenovirus is a promising vaccine vector for development of an HIV-1 vaccine and elicited by a replication-incompetent Ad5 vector, used either alone or as a booster inoculation after priming with a DNA vector.

TL;DR: Optimization of specific regulatory elements in the plasmid backbone can substantially improve the immunogenicity of DNA vaccines encoding multiple antigens in small animals and in nonhuman primates.

TL;DR: It is demonstrated that it is possible to generate protective immune responses by vaccination with genetically diverse isolates of HIV-1 and suggested that a multicomponent vaccine encoding Env proteins from multiple clades of HIV -1 can generate broad Env-specific T-lymphocyte and antibody responses without antigenic interference.

TL;DR: It is suggested that T-lymphocyte immunity to Env can broaden the protective cellular immune response to HIV despite significant sequence diversity of the strains of the Env immunogens and can contribute to immune protection in this AIDS vaccine model.

TL;DR: The extensive diversity of the rhesus monkey Kir3DL homologues and the novel KIR3DH and KIR1D molecules suggests that the KIR family of molecules has evolved rapidly during the evolution of primates.