A
Ayano Kondo
Researcher at University of Pennsylvania
Publications - 12
Citations - 1364
Ayano Kondo is an academic researcher from University of Pennsylvania. The author has contributed to research in topics: Cell type & Cellular differentiation. The author has an hindex of 5, co-authored 10 publications receiving 822 citations.
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Journal ArticleDOI
Single-cell transcriptomics of the mouse kidney reveals potential cellular targets of kidney disease
Jihwan Park,Rojesh Shrestha,Chengxiang Qiu,Ayano Kondo,Shizheng Huang,Max Werth,Mingyao Li,Jonathan Barasch,Katalin Susztak +8 more
TL;DR: It is inferred that inherited kidney diseases that arise from distinct genetic mutations but share the same phenotypic manifestation originate from the same differentiated cell type, and that the collecting duct in kidneys of adult mice generates a spectrum of cell types through a newly identified transitional cell.
Journal ArticleDOI
Subepithelial telocytes are an important source of Wnts that supports intestinal crypts
Michal Shoshkes-Carmel,Yue J. Wang,Kirk J. Wangensteen,Beáta Tóth,Ayano Kondo,Efi E. Massasa,Shalev Itzkovitz,Klaus H. Kaestner +7 more
TL;DR: Subepithelial telocytes are identified as a source of Wnt signals that enable proliferation and differentiation of intestinal stem cells, an essential function for maintenance of the intestinal epithelium.
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Single cell regulatory landscape of the mouse kidney highlights cellular differentiation programs and disease targets.
Zhen Miao,Michael S. Balzer,Ziyuan Ma,Hongbo Liu,Junnan Wu,Rojesh Shrestha,Tamás Arányi,Amy Kwan,Ayano Kondo,Marco Pontoglio,Junhyong Kim,Mingyao Li,Klaus H. Kaestner,Katalin Susztak +13 more
TL;DR: In this article, the authors profile open chromatin and gene expression in developing and adult mouse kidneys at single cell resolution and reveal key cell type-specific transcription factors and major gene-regulatory circuits for kidney cells.
Journal ArticleDOI
Emerging diverse roles of telocytes.
Ayano Kondo,Klaus H. Kaestner +1 more
TL;DR: The discovery of telocytes, their physical properties, distribution and function, focusing on recent developments in the functional analysis of Foxl1-positive telocytes in the intestinal stem cell niche, and, finally, the current challenges of studying telocytes as a distinct cell type are discussed.
Journal ArticleDOI
Single-cell multi-omics analysis of human pancreatic islets reveals novel cellular states in Type 1 Diabetes
Maria Danielle Fasolino,Gregory W. Schwartz,Aanchal Mongia,Maria L. Golson,Yue J. Wang,Ashleigh Morgan,Jonathan Schug,Jinping Liu,Minghui Wu,Ayano Kondo,Catherine Lee May,Naomi Goldman,Wenliang Wang,Michael Feldman,Jason H. Moore,Alberto Sada Japp,Michael R. Betts,Abhijeet Patil,Chengyang Liu,Daniel Traum,Robert B. Faryabi,Ali Naji,Golnaz Vahedi,Klaus H. Kaestner +23 more
TL;DR: In this paper , a single-cell atlas of pancreatic islets of 24 T1D, autoantibody-positive and non-diabetic organ donors was provided.