Ayla Aksoy-Aksel

TL;DR: Overexpression and knockdown of miR-181a in primary neurons demonstrated that this miRNA is a negative posttranscriptional regulator of GluA2 expression, and overexpression reduced GLUA2 surface expression, spine formation, and miniature excitatory postsynaptic current (mEPSC) frequency in hippocampal neurons, suggesting that miR

TL;DR: How neuronal activity influences each step in the lifetime of miRNAs, including the regulation of transcription, maturation, gene regulatory function and turnover in mammals is summarized.

TL;DR: Ube3a1 RNA, a transcript that encodes a truncated U be3a protein lacking catalytic activity, prevents exuberant dendrite growth and promotes spine maturation in rat hippocampal neurons and defines a noncoding function of an alternative Ube3A transcript in dendritic protein synthesis, with potential implications for Angelman syndrome and ASD.

TL;DR: A novel activity‐dependent miRNA/RBP crosstalk during synaptic scaling is identified, with potential implications for neural network homeostasis and epileptogenesis.

TL;DR: Together, two novel factors that control neuronal miRISC function at the level of Ago proteins are uncovered, with possible implications for the regulation of synapse development and plasticity.