A
Ayse Ulusoy
Researcher at German Center for Neurodegenerative Diseases
Publications - 38
Citations - 1991
Ayse Ulusoy is an academic researcher from German Center for Neurodegenerative Diseases. The author has contributed to research in topics: Neurodegeneration & Substantia nigra. The author has an hindex of 20, co-authored 34 publications receiving 1585 citations. Previous affiliations of Ayse Ulusoy include Hacettepe University & Lund University.
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Journal ArticleDOI
Caudo-rostral brain spreading of α-synuclein through vagal connections.
Ayse Ulusoy,Raffaella Rusconi,Blanca I. Pérez‐Revuelta,Ruth E. Musgrove,Michael Helwig,Bettina Winzen‐Reichert,Donato A. Di Monte +6 more
TL;DR: Overexpression of human α‐synuclein in the lower brainstem is sufficient to induce its long‐distance caudo‐rostral propagation, recapitulating features of Parkinson's disease and mechanisms of disease progression.
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α-Synuclein expression and Nrf2 deficiency cooperate to aggravate protein aggregation, neuronal death and inflammation in early-stage Parkinson's disease
Isabel Lastres-Becker,Ayse Ulusoy,Ayse Ulusoy,Nadia G. Innamorato,Gurdal Sahin,Alberto Rábano,Deniz Kirik,Antonio Cuadrado +7 more
TL;DR: It is demonstrated that α-SYN and Nrf2 deficiency cooperate on protein aggregation, neuroinflammation and neuronal death and provides a bifactorial animal model to study early-stage PD.
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GDNF fails to exert neuroprotection in a rat α-synuclein model of Parkinson’s disease
Mickael Decressac,Ayse Ulusoy,Bengt Mattsson,Biljana Georgievska,Marina Romero-Ramos,Deniz Kirik,Anders Björklund +6 more
TL;DR: Viral vector-mediated delivery of glial cell line-derived neurotrophic factor into substantia nigra and/or striatum was inefficient in preventing the wild-type α-synuclein-induced loss of dopamine neurons and terminals and did not ameliorate the behavioural deficit in this rat model of Parkinson's disease.
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Brain-to-stomach transfer of α-synuclein via vagal preganglionic projections.
Ayse Ulusoy,Robert J. Phillips,Michael Helwig,Michael Klinkenberg,Terry L. Powley,Donato A. Di Monte +5 more
TL;DR: Results of this in vivo study revealed a route-specific transmission of α-synuclein from the rat brain to the stomach, and the dorsal motor nucleus of the vagus nerve represents a key relay center for central-to-peripheral α- synuclein transmission, and efferent vagal fibers may act as unique conduits for protein transfer.
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LRRK2 kinase regulates α-synuclein propagation via RAB35 phosphorylation.
Eun Jin Bae,Dong Kyu Kim,Changyoun Kim,Changyoun Kim,Michael Mante,Anthony Adame,Edward Rockenstein,Ayse Ulusoy,Michael Klinkenberg,Ga Ram Jeong,Jae Ryul Bae,Cheol Soon Lee,He Jin Lee,Byung Dae Lee,Donato A. Di Monte,Eliezer Masliah,Eliezer Masliah,Seung-Jae Lee +17 more
TL;DR: It is demonstrated in cell culture, nematode, and rodent models of PD that leucine-rich repeat kinase 2 (LRRK2), a PD-linked kinase, modulates α-synuclein propagation in a kinase activity-dependent manner and that this is dependent on phosphorylation of one of its substrates, RAB35.