scispace - formally typeset
Search or ask a question
Author

Azila Abd. Aziz

Bio: Azila Abd. Aziz is an academic researcher from Universiti Teknologi Malaysia. The author has contributed to research in topics: Swietenia mahagoni & Supercritical fluid extraction. The author has an hindex of 6, co-authored 21 publications receiving 232 citations.

Papers
More filters
Journal ArticleDOI
TL;DR: In this paper, a review of the green synthesis of silver nanoparticles is presented, which showed more cost-effective and environmental friendly application as well as easier for large production, with relation to the properties of the nanoparticles as antimicrobial, can be served as an alternative antiseptic agent in various fields.
Abstract: In this century, the development of nanotechnology is projected to be the establishment of a technological evolutionary of this modern era. Recently, nanotechnology is one of the most active subjects of substantial research in modern material sciences and hence metal nanoparticles have a great scientific interest because of their unique optoelectronic and physicochemical properties with applications in diverse areas such as electronics, catalysis, drug delivery, or sensing. Nanotechnology provides an understanding on fundamental properties of objects at the atomic, molecular, and supramolecular levels. Besides, nanotechnology also leads an alternative technological pathway for the exploration and revolution of biological entities, whereas biology provides role models and biosynthetic constituents to nanotechnology. The findings of this review are important to provide an alternative for the green synthesis of silver nanoparticles. It showed more cost-effective and environmental friendly application as well as easier for large production, with relation to the properties of silver nanoparticles as antimicrobial, can be served well as an alternative antiseptic agent in various fields. Typically, silver nanoparticles are smaller than 100 nm and consist of about 20–15,000 silver atoms. Due to the attractive physical and chemical properties of silver at the nanoscale, the development of silver nanoparticles is expanding in recent years and is nowadays significant for consumer and medical products.

230 citations

Journal ArticleDOI
20 Apr 2021-Polymers
TL;DR: In this article, the authors highlight the recent successful research outcomes of stimuli-responsive in situ gelling systems in treating in vivo models with glaucoma and various ocular infections, and present the mechanism, recent development, and safety considerations of stimuli sensitive in situ gel as the potential sustained ocular delivery system for treating common eye disorders.
Abstract: Eyesight is one of the most well-deserved blessings, amid all the five senses in the human body. It captures the raw signals from the outside world to create detailed visual images, granting the ability to witness and gain knowledge about the world. Eyes are exposed directly to the external environment; they are susceptible to the vicissitudes of diseases. The World Health Organization has predicted that the number of individuals affected by eye diseases will rise enormously in the next decades. However, the physical barriers of the eyes and the problems associated with conventional ocular formulations are significant challenges in ophthalmic drug development. This has generated the demand for a sustained ocular drug delivery system, which serves to deliver effective drug concentration at a reduced frequency for consistent therapeutic effect and better patient treatment adherence. Recent advancement in pharmaceutical dosage design has demonstrated that a stimuli-responsive in situ gel system exhibits the favorable characteristics for providing sustained ocular drug delivery and enhanced ocular bioavailability. Stimuli-responsive in situ gels undergo a phase transition (solution–gelation) in response to the ocular environmental temperature, pH, and ions. These stimuli transform the formulation into a gel at the cul de sac to overcome the shortcomings of conventional eye drops, such as rapid nasolacrimal drainage and short contact time with the ocular surface This review highlights the recent successful research outcomes of stimuli-responsive in situ gelling systems in treating in vivo models with glaucoma and various ocular infections. Additionally, it also presents the mechanism, recent development, and safety considerations of stimuli-sensitive in situ gel as the potential sustained ocular delivery system for treating common eye disorders.

22 citations

Journal ArticleDOI
TL;DR: Virgin coconut oil (VCO) is the finest grade of coconut oil, rich in phenolic content, antioxidant activity and contains medium chain triglycerides (MCTs) which have the potential to be exploited as a micro/nano scale cosmeceutical carrying vehicle for improved dermal delivery of VCO.
Abstract: Virgin coconut oil (VCO) is the finest grade of coconut oil, rich in phenolic content, antioxidant activity and contains medium chain triglycerides (MCTs). In this work formulation, characterisation and penetration of VCO-solid lipid particles (VCO-SLP) have been studied. VCO-SLP were prepared using ultrasonication of molten stearic acid and VCO in an aqueous solution. The electron microscopy imaging revealed that VCO-SLP were solid and spherical in shape. Ultrasonication was performed at several power intensities which resulted in particle sizes of VCO-SLP ranged from 0.608 ± 0.002 µm to 44.265 ± 1.870 µm. The particle size was directly proportional to the applied power intensity of ultrasonication. The zeta potential values of the particles were from -43.2 ± 0.28 mV to -47.5 ± 0.42 mV showing good stability. The cumulative permeation for the smallest sized VCO-SLP (0.608 µm) was 3.83 ± 0.01 µg/cm(2) whereas for larger carriers it was reduced (3.59 ± 0.02 µg/cm(2)). It is concluded that SLP have the potential to be exploited as a micro/nano scale cosmeceutical carrying vehicle for improved dermal delivery of VCO.

12 citations

01 Jan 2015
TL;DR: In this paper, the authors presented the formulation of nanostructured lipid carrier encapsulated Zingiber zerumbet oil (NLC-ZZ) using ultrasonication technique.
Abstract: This study presents the formulation of nanostructured lipid carrier encapsulated Zingiber zerumbet oil (NLC-ZZ) using ultrasonication technique. NLC is the blend of solid lipid, liquid lipid and surfactant for encapsulation of poor water soluble actives. The NLC-ZZ formulation was characterized with respect to particle size, polydispersity index (PDI), zeta-potential, encapsulation efficiency and physical morphology. The NLC-ZZ formulation had an average diameter of 96.59 nm, PDI of 0.192, zeta-potential of -39.88 mV, and encapsulation efficiency of 90%, respectively. The NLC formulation for Zingiber zerumbet oil encapsulation has been successfully developed and is suitable for transdermal delivery system due to their nano-size and stability. Copyright © 2015 Penerbit Akademia Baru All rights reserved.

11 citations

01 Oct 2008
TL;DR: In this paper, a new delivery system for mosquito repellent based on the incorporation of geranium oil into solid lipid nanoparticles (SLNs) has been studied, and the results showed that the variation in the amount of ingredients affected Geranium oil loading capacity and mean particle size.
Abstract: In recent years, essential oil has been the subject matter of many investigations due to its eco-friendly and bio-degradable nature. Geranium oil is one of the various essential oils that are used as mosquito repellent. However, stability is one of the issues related to essential oil fonnulations. Incorporation of essential oil in a control-release formulation could solve the problem and it also offers several advantages. In this work, a new delivery system for mosquito repellent based on the incorporation of geranium oil into solid lipid nanoparticles (SLNs) has been studied. The following has been employed for the production of geranium oil loaded solid lipid nanoparticles (GO-SLNs): 5-15% (w/w) stearic acid as the lipid, 0.5-3% (w/w) soy lecithin as the emulsifier, 0.5-3% (w/w) Tween 80 as the co-emulsifier, 5-20% (w/w) dichloromethane also as the co-emulsifier and 8% (w/w) geranium oil as the active ingredient. GO-SLNs were prepared using ultrasonicsolvent emulsification technique. GO-SLNS were characterized using transmission electron microscopy (TEM), photon cross correlation spectroscopy (PCCS), gel filtration and gas chromatography (GC). Results showed that the variation in the amount of ingredients affected geranium oil loading capacity and mean particle size. Increasing the concentrations of lipid, emulsifier and co-emulsifier resulted in the increase in the mean particle size from 46 nm to 114 nm. Geranium oil encapsulation efficiency (EE) was in the range of 92-99% (w/w). Production of high quality SLNS loaded with geranium oil has been demonstrated.

10 citations


Cited by
More filters
Journal Article
TL;DR: This book by a teacher of statistics (as well as a consultant for "experimenters") is a comprehensive study of the philosophical background for the statistical design of experiment.
Abstract: THE DESIGN AND ANALYSIS OF EXPERIMENTS. By Oscar Kempthorne. New York, John Wiley and Sons, Inc., 1952. 631 pp. $8.50. This book by a teacher of statistics (as well as a consultant for \"experimenters\") is a comprehensive study of the philosophical background for the statistical design of experiment. It is necessary to have some facility with algebraic notation and manipulation to be able to use the volume intelligently. The problems are presented from the theoretical point of view, without such practical examples as would be helpful for those not acquainted with mathematics. The mathematical justification for the techniques is given. As a somewhat advanced treatment of the design and analysis of experiments, this volume will be interesting and helpful for many who approach statistics theoretically as well as practically. With emphasis on the \"why,\" and with description given broadly, the author relates the subject matter to the general theory of statistics and to the general problem of experimental inference. MARGARET J. ROBERTSON

13,333 citations

Journal ArticleDOI
TL;DR: The methods of making nanoparticles using plant extracts are reviewed, methods of particle characterization are reviewed and potential applications of the particles in medicine are discussed.

1,706 citations

Journal ArticleDOI
TL;DR: A state-of-the-art review on the synthesis of AgNPs, and their applications in antimicrobial textile fabrics, food packaging films, and wound dressings is provided.
Abstract: Silver nanoparticles (AgNPs) can be synthesized from a variety of techniques including physical, chemical and biological routes. They have been widely used as nanomaterials for manufacturing cosmetic and healthcare products, antimicrobial textiles, wound dressings, antitumor drug carriers, etc. due to their excellent antimicrobial properties. Accordingly, AgNPs have gained access into our daily life, and the inevitable human exposure to these nanoparticles has raised concerns about their potential hazards to the environment, health, and safety in recent years. From in vitro cell cultivation tests, AgNPs have been reported to be toxic to several human cell lines including human bronchial epithelial cells, human umbilical vein endothelial cells, red blood cells, human peripheral blood mononuclear cells, immortal human keratinocytes, liver cells, etc. AgNPs induce a dose-, size- and time-dependent cytotoxicity, particularly for those with sizes ≤10 nm. Furthermore, AgNPs can cross the brain blood barrier of mice through the circulation system on the basis of in vivo animal tests. AgNPs tend to accumulate in mice organs such as liver, spleen, kidney and brain following intravenous, intraperitoneal, and intratracheal routes of administration. In this respect, AgNPs are considered a double-edged sword that can eliminate microorganisms but induce cytotoxicity in mammalian cells. This article provides a state-of-the-art review on the synthesis of AgNPs, and their applications in antimicrobial textile fabrics, food packaging films, and wound dressings. Particular attention is paid to the bactericidal activity and cytotoxic effect in mammalian cells.

510 citations

Journal ArticleDOI
TL;DR: The present review highlights the antimicrobial effects of various nanomaterials and their potential advantages, drawbacks, or side effects and may be useful in the discovery of broad-spectrum antimicrobial drugs for use against multi-drug-resistant microbial pathogens in the near future.
Abstract: Antimicrobial substances may be synthetic, semisynthetic, or of natural origin (i.e., from plants and animals). Antimicrobials are considered “miracle drugs” and can determine if an infected patient/animal recovers or dies. However, the misuse of antimicrobials has led to the development of multi-drug-resistant bacteria, which is one of the greatest challenges for healthcare practitioners and is a significant global threat. The major concern with the development of antimicrobial resistance is the spread of resistant organisms. The replacement of conventional antimicrobials by new technology to counteract antimicrobial resistance is ongoing. Nanotechnology-driven innovations provide hope for patients and practitioners in overcoming the problem of drug resistance. Nanomaterials have tremendous potential in both the medical and veterinary fields. Several nanostructures comprising metallic particles have been developed to counteract microbial pathogens. The effectiveness of nanoparticles (NPs) depends on the interaction between the microorganism and the NPs. The development of effective nanomaterials requires in-depth knowledge of the physicochemical properties of NPs and the biological aspects of microorganisms. However, the risks associated with using NPs in healthcare need to be addressed. The present review highlights the antimicrobial effects of various nanomaterials and their potential advantages, drawbacks, or side effects. In addition, this comprehensive information may be useful in the discovery of broad-spectrum antimicrobial drugs for use against multi-drug-resistant microbial pathogens in the near future.

365 citations

Journal ArticleDOI
TL;DR: It is expected that metal-supported nanomaterials play an outstanding role not only in medical but also in other important areas such as antibacterial, antifungal, anticancer, and so on.
Abstract: Nanoparticles (nanoparticles) have received much attention in biological application because of their unique physicochemical properties. The metal- and metal oxide-supported nanomaterials have shown significant therapeutic effect in medical science. The mechanisms related to the interaction of nanoparticles with animal and plant cells can be used to establish its significant role and to improve their activity in health and medical applications. Various attempts have been made to discuss the antibiotic resistance and antimicrobial activity of metal-supported nanoparticles. Despite all these developments, there is still a need to investigate their performance to overcome modern challenges. In this regard, the present review examines the role of various types of metal-supported nanomaterials in different areas such as antibacterial, antifungal, anticancer, and so on. Based on the significant ongoing research and applications, it is expected that metal-supported nanomaterials play an outstanding role not only in medical but also in other important areas.

319 citations