5.1. Detection Formats 475 5.2. Food Quality and Safety Analysis 477 5.2.1. Pathogens 477 5.2.2. Toxins 479 5.2.3. Veterinary Drugs 479 5.2.4. Vitamins 480 5.2.5. Hormones 480 5.2.6. Diagnostic Antibodies 480 5.2.7. Allergens 481 5.2.8. Proteins 481 5.2.9. Chemical Contaminants 481 5.3. Medical Diagnostics 481 5.3.1. Cancer Markers 481 5.3.2. Antibodies against Viral Pathogens 482 5.3.3. Drugs and Drug-Induced Antibodies 483 5.3.4. Hormones 483 5.3.5. Allergy Markers 483 5.3.6. Heart Attack Markers 484 5.3.7. Other Molecular Biomarkers 484 5.4. Environmental Monitoring 484 5.4.1. Pesticides 484 5.4.2. 2,4,6-Trinitrotoluene (TNT) 485 5.4.3. Aromatic Hydrocarbons 485 5.4.4. Heavy Metals 485 5.4.5. Phenols 485 5.4.6. Polychlorinated Biphenyls 487 5.4.7. Dioxins 487 5.5. Summary 488 6. Conclusions 489 7. Abbreviations 489 8. Acknowledgment 489 9. References 489

Surface Plasmon Resonance Sensors for Detection of Chemical and Biological Species

The emerging field of nanophotonics1 addresses the critical challenge of manipulating light on scales much smaller than the wavelength. However, very few feasible practical approaches exist at present. Surface plasmon polaritons2,3 are among the most promising candidates for subwavelength optical confinement3,4,5,6,7,8,9,10. However, studies of long-range surface plasmon polaritons have only demonstrated optical confinement comparable to that of conventional dielectric waveguides, because of practical issues including optical losses and stringent fabrication demands3,11,12,13. Here, we propose a new approach that integrates dielectric waveguiding with plasmonics. The hybrid optical waveguide consists of a dielectric nanowire separated from a metal surface by a nanoscale dielectric gap. The coupling between the plasmonic and waveguide modes across the gap enables ‘capacitor-like’ energy storage that allows effective subwavelength transmission in non-metallic regions. In this way, surface plasmon polaritons can travel over large distances (40–150 µm) with strong mode confinement (ranging from λ2/400 to λ2/40). This approach is fully compatible with semiconductor fabrication techniques and could lead to truly nanoscale semiconductor-based plasmonics and photonics. Xiang Zhang and colleagues from the University of California, Berkeley, propose a new approach for confining light on scales much smaller than the wavelength of light. Using hybrid waveguides that incorporate dielectric and plasmonic waveguiding techniques, they are able to confine surface plasmon polaritons very strongly over large distances. The advance could lead to truly nanoscale plasmonics and photonics.

/pdf/a-hybrid-plasmonic-waveguide-for-subwavelength-confinement-3aah5h2zn4.pdf

A hybrid plasmonic waveguide for subwavelength confinement and long-range propagation

technology. This has been necessitated by the need to access hostile or difficult environments in situ and in vivo. strategies to date have included the use of specialist fibres and miniaturized scanning systems accompanied by ingenious microfabricated lenses. Here we present a novel approach for this field by utilizing disordered light within a standard multimode optical fibre for lensless microscopy and optical mode conversion. We demonstrate the modalities of bright- and dark-field imaging and scanning fluorescence microscopy at acquisition rates that allow observation of dynamic processes such as Brownian motion of mesoscopic particles. Furthermore, we show how such control can realize a new form of mode converter and generate various types of advanced light fields such as propagation-invariant beams and optical vortices. These may be useful for future fibre-based implementations of super-resolution or light-sheet microscopy.

/pdf/exploiting-multimode-waveguides-for-pure-fibre-based-imaging-4x1zc2gqff.pdf

Exploiting multimode waveguides for pure fibre-based imaging

The prediction of light propagation up to hundreds of millimetres within straight or even deformed segments of multimode fibres is demonstrated. The concept is applied in an endoscope and exceptional resolution and footprint are obtained.

Seeing through chaos in multimode fibres

Optical Surface plasmon resonance (SPR) biosensors represent the most advanced and developed optical label-free biosensor technology. Optical SPR biosensors are a powerful detection and analysis tool that has vast applications in environmental protection, biotechnology, medical diagnostics, drug screening, food safety and security. This article reviews the recent development of SPR biosensor techniques, including bulk SPR and localized SPR (LSPR) biosensors, for detecting interactions between an analyte of interest in solution and a biomolecular recognition. The concepts of bulk and localized SPs and the working principles of both sensing techniques are introduced. Major sensing advances on biorecognition elements, measurement formats, and sensing platforms are presented. Finally, the discussions on both biosensor techniques as well as comparison of both SPR sensing techniques are made.

Azzedine Boudrioua

Papers

Optical Waveguide Theory