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B. Franklin Pugh
Researcher at Pennsylvania State University
Publications - 116
Citations - 15992
B. Franklin Pugh is an academic researcher from Pennsylvania State University. The author has contributed to research in topics: Transcription factor II D & RNA polymerase II. The author has an hindex of 58, co-authored 111 publications receiving 14718 citations. Previous affiliations of B. Franklin Pugh include Tongji University & University of Wisconsin-Madison.
Papers
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Journal ArticleDOI
Nucleosome positioning and gene regulation: advances through genomics
Cizhong Jiang,B. Franklin Pugh +1 more
TL;DR: What high-resolution genome-wide maps of nucleosomes positions have taught us about how nucleosome positioning demarcates promoter regions and transcriptional start sites and how the composition and structure of promoter nucleosites facilitate or inhibit transcription is discussed.
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Mechanism of transcriptional activation by Sp1: evidence for coactivators.
B. Franklin Pugh,Robert Tjian +1 more
TL;DR: These findings with Sp1 and CTF suggest that partially purified TFIID fractions from human and Drosophila cells contain coactivators that are dispensable for basal transcription but are required as molecular adaptors between trans-activators and the general transcription initiation machinery.
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Comprehensive Genome-wide Protein-DNA Interactions Detected at Single Nucleotide Resolution
Ho Sung Rhee,B. Franklin Pugh +1 more
TL;DR: It is found that binding sites become unambiguous and reveal diverse tendencies governing in vivo DNA-binding specificity that include sequence variants, functionally distinct motifs, motif clustering, secondary interactions, and combinatorial modules within a compound motif.
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Nucleosome organization in the Drosophila genome
Travis N. Mavrich,Cizhong Jiang,Ilya Ioshikhes,Xiao-Yong Li,Bryan J. Venters,Sara J. Zanton,Lynn P. Tomsho,Ji Qi,Robert L. Glaser,Stephan C. Schuster,David S. Gilmour,Istvan Albert,B. Franklin Pugh +12 more
TL;DR: A high-resolution reference map of H2A.Z and bulk nucleosome locations across the genome of the fly Drosophila melanogaster is produced and that from the yeast Saccharomyces cerevisiae is compared.
Journal ArticleDOI
Translational and rotational settings of H2A.Z nucleosomes across the Saccharomyces cerevisiae genome
Istvan Albert,Travis N. Mavrich,Lynn P. Tomsho,Ji Qi,Sara J. Zanton,Stephan C. Schuster,B. Franklin Pugh +6 more
TL;DR: The sequence of 322,000 individual Saccharomyces cerevisiae nucleosomes, containing the histone variant H2A.Z, reveals an intimate relationship between chromatin architecture and the underlying DNA sequence it regulates.