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B. Lawrence Riggs
Researcher at Mayo Clinic
Publications - 220
Citations - 40612
B. Lawrence Riggs is an academic researcher from Mayo Clinic. The author has contributed to research in topics: Osteoporosis & Bone remodeling. The author has an hindex of 105, co-authored 220 publications receiving 39218 citations. Previous affiliations of B. Lawrence Riggs include University of Vermont & University of Rochester.
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Journal ArticleDOI
Sex steroids and the construction and conservation of the adult skeleton.
TL;DR: A new unitary model for the pathophysiology of involutional osteoporosis is reviewed and extended that identifies estrogen (E) as the key hormone for maintaining bone mass and E deficiency as the major cause of age-related bone loss in both sexes.
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Perspective : how many women have osteoporosis ?
TL;DR: Osteoporosis is widely viewed as a major public health concern, but the exact magnitude of the problem is uncertain and likely to depend on how the condition is defined, and the design and implementation of control programs directed at this major health problem must be given.
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A Unitary Model for Involutional Osteoporosis: Estrogen Deficiency Causes Both Type I and Type II Osteoporosis in Postmenopausal Women and Contributes to Bone Loss in Aging Men
TL;DR: A new unitary model for the pathophysiology of involutional osteoporosis is proposed that identifies estrogen (E) deficiency as the cause of both the early, accelerated and the late, slow phases of bone loss in postmenopausal women and as a contributing cause of the continuous phase ofBone loss in aging men.
Journal ArticleDOI
Effect of fluoride treatment on the fracture rate in postmenopausal women with osteoporosis.
B. Lawrence Riggs,Stephen F. Hodgson,W. Michael O'Fallon,Edmund Y. S. Chao,Heinz W. Wahner,Joan M. Muhs,Sandra L. Cedel,L. Joseph Melon +7 more
TL;DR: It is concluded that fluoride therapy increases cancellous but decreases cortical bone mineral density and increases skeletal fragility, and the fluoride-calcium regimen was not effective treatment for postmenopausal osteoporosis.
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Relationship of serum sex steroid levels and bone turnover markers with bone mineral density in men and women: A key role for bioavailable estrogen
Sundeep Khosla,L. Joseph Melton,Elizabeth J. Atkinson,W. M. O'Fallon,George G. Klee,B. Lawrence Riggs +5 more
TL;DR: It is shown that age-related bone loss may be the result of E deficiency not just in postmenopausal women, but also in men, and bioavailable E levels decline significantly with age and are important predictors of BMD in men as well as women.