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B. Shivarama Holla

Bio: B. Shivarama Holla is an academic researcher from Mangalore University. The author has contributed to research in topics: Antibacterial activity & Antibacterial agent. The author has an hindex of 21, co-authored 92 publications receiving 2243 citations.


Papers
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Journal ArticleDOI
TL;DR: A series of 3-substituted 4-[5-(4-methoxy-2-nitrophenyl)-2-furfurylidene] amino-5-mercapto-1,2,4-triazoles synthesized were screened for their anticancer activity against a panel of 60 cell lines derived from seven cancer types namely, lung, colon, melanoma, renal, ovarian, CNS and leukemia.

423 citations

Journal ArticleDOI
TL;DR: The newly synthesised compounds were screened for their anticancer activity against a panel of 60 cell lines derived from seven cancer types namely, lung, colon, melanoma, renal, ovarian, CNS and leukemia and showed promising anticancer properties.

343 citations

Journal ArticleDOI
TL;DR: A series of arylthioureas, aromatic aldehyde thiosemicarbazones, and 5-aryl-2-furfuraldehyde thIosemicarazones were condensed with 2,4-dichloro-5-fluorophenacyl bromide to yield respective arylaminothiazoles, aryLidene/5- Daryl-2 -furfurylidene hydrazinothia

245 citations

Journal ArticleDOI
TL;DR: The newly synthesized compounds 3m, 3o, 3q showed in vitro anticancer activity and were tested for their antimicrobial activities against Escherichia coli, Staphylococcus aureus, Psuedomonas aeruginosa, Bacillus subtilis and Candida albicans.

106 citations

Journal ArticleDOI
TL;DR: Three compounds exhibited in vitro antitumor activity with moderate to excellent growth inhibition against a panel of sixty cancer cell lines of leukemia, non-small cell lung cancer, melanoma, ovarian cancer, prostate and breast cancer.

104 citations


Cited by
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Journal ArticleDOI
TL;DR: A series of 2,4-dichloro-5-fluorophenyl bearing Mannich base was prepared from triazole Schiff bases by aminomethylation with formaldehyde and secondary/substituted primary amines to show promising antibacterial and antifungal activity.

460 citations

Journal ArticleDOI
TL;DR: A series of 3-substituted 4-[5-(4-methoxy-2-nitrophenyl)-2-furfurylidene] amino-5-mercapto-1,2,4-triazoles synthesized were screened for their anticancer activity against a panel of 60 cell lines derived from seven cancer types namely, lung, colon, melanoma, renal, ovarian, CNS and leukemia.

423 citations

Journal ArticleDOI
TL;DR: This paper is an attempt to review the pharmacological activities reported for triazole derivatives in the current literature with an update of recent research findings on this nuclei.
Abstract: The triazole nucleus is one of the most important and well known heterocycles which is a common and integral feature of a variety of natural products and medicinal agents. Triazole nucleus is present as a core structural component in an array of drug categories such as antimicrobial, anti-inflammatory, analgesic, antiepileptic, antiviral, antineoplastic, antihypertensive, antimalarial, local anaesthetic, antianxiety, antidepressant, antihistaminic, antioxidant, antitubercular, anti-Parkinson's, antidiabetic, antiobesity and immunomodulatory agents, etc. The broad and potent activity of triazole and their derivatives has established them as pharmacologically significant scaffolds. The basic heterocyclic rings present in the various medicinal agents are 1,2,3-triazole and 1,2,4-triazole. A large volume of research has been carried out on triazole and their derivatives, which has proved the pharmacological importance of this heterocyclic nucleus. The present paper is an attempt to review the pharmacological activities reported for triazole derivatives in the current literature with an update of recent research findings on this nuclei.

398 citations

Journal ArticleDOI
TL;DR: Among the tested compounds, the most effective compounds with MIC value in the range of 6.25-25 microg/ml are 4a, 4n, 4z, 5a, 5b, 6a and 6b against three fungal strains viz.

310 citations

Journal ArticleDOI
TL;DR: The most important biological effects of thiazole-based compounds are reviewed and their roles in new leads identification and drug discovery are highlighted to help researches for finding potential future directions on the development of more potent and specific analogs of th Diazole- based compounds for various biological targets.

266 citations