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Bachar Zebib

Bio: Bachar Zebib is an academic researcher from University of Toulouse. The author has contributed to research in topics: Essential oil & Tussilago. The author has an hindex of 10, co-authored 30 publications receiving 997 citations. Previous affiliations of Bachar Zebib include Centre national de la recherche scientifique & Pierre-and-Marie-Curie University.

Papers
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Journal ArticleDOI
TL;DR: This comprehensive review article spots the light on one of the most interesting microalga Chlorella vulgaris and assembles the history and a thorough description of its ultrastructure and composition according to growth conditions.
Abstract: Economic and technical problems related to the reduction of petroleum resources require the valorisation of renewable raw material Recently, microalgae emerged as promising alternative feedstock that represents an enormous biodiversity with multiple benefits exceeding the potential of conventional agricultural feedstock Thus, this comprehensive review article spots the light on one of the most interesting microalga Chlorella vulgaris It assembles the history and a thorough description of its ultrastructure and composition according to growth conditions The harvesting techniques are presented in relation to the novel algo-refinery concept, with their technological advancements and potential applications in the market

677 citations

Journal ArticleDOI
TL;DR: The microalgal structure has been investigated to evaluate the release of proteins in aqueous media from five microalgae after conducting different cell disruption techniques: manual grinding, ultrasonication, alkaline treatment, and high-pressure treatment.
Abstract: The microalgal structure has been investigated to evaluate the release of proteins in aqueous media from five microalgae after conducting different cell disruption techniques: manual grinding, ultrasonication, alkaline treatment, and high-pressure treatment. After conducting cell disruption, the protein concentration in water was determined for all the microalgae and the results are discussed within the context of their cell wall structure. It was found that the aqueous media containing most protein concentration followed the order: high-pressure cell disruption>chemical treatment>ultrasonication>manual grinding. Fragile cell-walled microalgae were mostly attacked according to the following order: Haematococcus pluvialis < Nannochloropsis oculata < Chlorella vulgaris < Porphyridium cruentum ≤ Arthrospira platensis.

255 citations

Journal ArticleDOI
TL;DR: On evaluation of in vitro stability, all complexes were found to provide a higher stability from curcumin alone, compared to cur cumin alone.
Abstract: The purpose of present study was to stabilize curcumin food pigment by its complexation with divalent ions like (Zn(2+), Cu(2+), Mg(2+), Se(2+)), in "green media" and evaluate its stability in vitro compared to curcumin alone. The curcumin complexes were prepared by mechanical mixture of curcumin and sulfate salts of each metal (metal : curcumin 1/1mol) into unconventional and nontoxic glycerol/water solvent. Two stoichiometry of complex were obtained, 1 : 1 and 1 : 2 (metal/curcumin), respectively. On evaluation of in vitro stability, all complexes were found to provide a higher stability from curcumin alone.

138 citations

Journal ArticleDOI
TL;DR: The results suggest that non-essential amino acids are more concentrated actually inside the cells and that different types of proteins are being released by these two treatments.
Abstract: In order to release proteins in the aqueous phase, high-pressure homogenization and alkaline treatments were applied to rupture the cell walls of five intensively grown microalgae. Protein characterisation was carried out by analysing the amino acid profiles of both the crude microalgae and the protein extracts, obtained after both types of treatment. The results showed that the proportion of proteins released from microalgae following both treatments was, in descending order: Porphyridium cruentum>Arthrospira platensis>Chlorella vulgaris>Nannochloropsis oculata>Haematococcus pluvialis, reflecting the increasingly protective, cell walls. Nonetheless, mechanical treatment released more proteins from all the microalgae compared to chemical treatment. The highest yield was for the fragile cell walled P. cruentum with 88% hydro-soluble proteins from total proteins, and the lowest from the rigid cell walled H. pluvialis with 41%. The proportion of essential and non-essential amino acids in the extract was assessed and compared to the crude microalgae profile. It was higher after alkaline treatment and much higher after high-pressure homogenization. These results suggest that non-essential amino acids are more concentrated actually inside the cells and that different types of proteins are being released by these two treatments.

60 citations

Journal ArticleDOI
26 Apr 2019-Agronomy
TL;DR: In this paper, the effect of salinity and water stresses on the essential oil components of Rosmarinus officinalis essential oil was investigated, and the results showed that non-irrigated rosemary plants showed the highest essential oil yield.
Abstract: The effect of salinity and water stresses on the essential oil components of Rosmarinus officinalis essential oil was investigated. Rosemary plants were submitted to different water treatments: tap water (TW), salt water (SW) and without irrigation (NIR). GC/MS analysis showed that ten and eleven volatile compounds were identified in essential oil of rosemary plants irrigated with tap water (TW) and salt water (SW), respectively. However, thirteen volatile compounds were identified in essential oil of non-irrigated plants (NIR). Moreover, among these compounds, α-Pinene, Eucalyptol (1,8 Cineol), Camphene, Borneol, D-verbenone, Bornyl acetate were the major components of oil. Also, GC/MS results highlighted that non-irrigated rosemary plants showed the highest essential oil yield (Y). Obtained oil yields followed the order YNIR > YTW > YSW. In conclusion, qualitative and quantitative differences in rosemary essential oil components were highlighted in relation to water stress.

39 citations


Cited by
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Journal ArticleDOI
TL;DR: This work highlights this rapidly advancing area of algal science with a particular focus on the key research required to assess better the health benefits of an alga or algal product.
Abstract: Global demand for macroalgal and microalgal foods is growing, and algae are increasingly being consumed for functional benefits beyond the traditional considerations of nutrition and health. There is substantial evidence for the health benefits of algal-derived food products, but there remain considerable challenges in quantifying these benefits, as well as possible adverse effects. First, there is a limited understanding of nutritional composition across algal species, geographical regions, and seasons, all of which can substantially affect their dietary value. The second issue is quantifying which fractions of algal foods are bioavailable to humans, and which factors influence how food constituents are released, ranging from food preparation through genetic differentiation in the gut microbiome. Third is understanding how algal nutritional and functional constituents interact in human metabolism. Superimposed considerations are the effects of harvesting, storage, and food processing techniques that can dramatically influence the potential nutritive value of algal-derived foods. We highlight this rapidly advancing area of algal science with a particular focus on the key research required to assess better the health benefits of an alga or algal product. There are rich opportunities for phycologists in this emerging field, requiring exciting new experimental and collaborative approaches.

933 citations

Journal ArticleDOI
TL;DR: This comprehensive review article spots the light on one of the most interesting microalga Chlorella vulgaris and assembles the history and a thorough description of its ultrastructure and composition according to growth conditions.
Abstract: Economic and technical problems related to the reduction of petroleum resources require the valorisation of renewable raw material Recently, microalgae emerged as promising alternative feedstock that represents an enormous biodiversity with multiple benefits exceeding the potential of conventional agricultural feedstock Thus, this comprehensive review article spots the light on one of the most interesting microalga Chlorella vulgaris It assembles the history and a thorough description of its ultrastructure and composition according to growth conditions The harvesting techniques are presented in relation to the novel algo-refinery concept, with their technological advancements and potential applications in the market

677 citations

Journal ArticleDOI
TL;DR: This review mainly focuses on the anti-inflammatory potential of curcumin and recent developments in dosage form and nanoparticulate delivery systems with the possibilities of therapeutic application ofCurcumin for the prevention and/or treatment of cancer.
Abstract: Oxidative damage and inflammation have been pointed out in preclinical studies as the root cause of cancer and other chronic diseases such as diabetes, hypertension, Alzheimer's disease, etc. Epidemiological and clinical studies have suggested that cancer could be prevented or significantly reduced by treatment with anti-oxidant and anti-inflammatory drugs, therefore, curcumin, a principal component of turmeric (a curry spice) showing strong anti-oxidant and anti-inflammatory activities, might be a potential candidate for the prevention and/or treatment of cancer and other chronic diseases. However, curcumin, a highly pleiotropic molecule with an excellent safety profile targeting multiple diseases with strong evidence on the molecular level, could not achieve its optimum therapeutic outcome in past clinical trials, largely due to its low solubility and poor bioavailability. Curcumin can be developed as a therapeutic drug through improvement in formulation properties or delivery systems, enabling its enhanced absorption and cellular uptake. This review mainly focuses on the anti-inflammatory potential of curcumin and recent developments in dosage form and nanoparticulate delivery systems with the possibilities of therapeutic application of curcumin for the prevention and/or treatment of cancer.

610 citations

Journal ArticleDOI
Guido Busca1

572 citations

Journal ArticleDOI
TL;DR: This review addresses the oncopharmacological properties of curcumin at the molecular level, whereby the phenotypical/biological changes induced in cancer cells upon completion of theCurcumin-triggered signaling cascade(s) are addressed in the framework of the hallmarks of cancer.
Abstract: This review addresses the oncopharmacological properties of curcumin at the molecular level. First, the interactions between curcumin and its molecular targets are addressed on the basis of curcumin's distinct chemical properties, which include H-bond donating and accepting capacity of the β-dicarbonyl moiety and the phenylic hydroxyl groups, H-bond accepting capacity of the methoxy ethers, multivalent metal and nonmetal cation binding properties, high partition coefficient, rotamerization around multiple C-C bonds, and the ability to act as a Michael acceptor. Next, the in vitro chemical stability of curcumin is elaborated in the context of its susceptibility to photochemical and chemical modification and degradation (e.g., alkaline hydrolysis). Specific modification and degradatory pathways are provided, which mainly entail radical-based intermediates, and the in vitro catabolites are identified. The implications of curcumin's (photo)chemical instability are addressed in light of pharmaceutical curcumin preparations, the use of curcumin analogues, and implementation of nanoparticulate drug delivery systems. Furthermore, the pharmacokinetics of curcumin and its most important degradation products are detailed in light of curcumin's poor bioavailability. Particular emphasis is placed on xenobiotic phase I and II metabolism as well as excretion of curcumin in the intestines (first pass), the liver (second pass), and other organs in addition to the pharmacokinetics of curcumin metabolites and their systemic clearance. Lastly, a summary is provided of the clinical pharmacodynamics of curcumin followed by a detailed account of curcumin's direct molecular targets, whereby the phenotypical/biological changes induced in cancer cells upon completion of the curcumin-triggered signaling cascade(s) are addressed in the framework of the hallmarks of cancer. The direct molecular targets include the ErbB family of receptors, protein kinase C, enzymes involved in prostaglandin synthesis, vitamin D receptor, and DNA.

411 citations