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Badri N. Pandey

Bio: Badri N. Pandey is an academic researcher from Homi Bhabha National Institute. The author has contributed to research in topics: Apoptosis & Cancer. The author has an hindex of 28, co-authored 106 publications receiving 2511 citations. Previous affiliations of Badri N. Pandey include Bhabha Atomic Research Centre & Rutgers University.


Papers
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Journal ArticleDOI
TL;DR: In this paper, the average crystallite sizes of Fe3O4-MN, Fe3 o4-OA-MN and Fe3 O4-PEG-MN were found to be 12, 6 and 8 nm.
Abstract: Fe3O4 magnetic nanoparticles (Fe3O4-MN) capped with either oleic acid (Fe3O4-OA-MN) or polyethylene glycol (Fe3O4-PEG-MN) were prepared by a co-precipitation method. From X-ray diffraction studies, the average crystallite sizes of Fe3O4-MN, Fe3O4-OA-MN and Fe3O4-PEG-MN were found to be 12, 6 and 8 nm, respectively. A reduction in the agglomeration of particles was observed when the magnetic nanoparticles (MN) were capped with oleic acid (OA) and polyethylene glycol (PEG), as confirmed by a transmission electron microscopy study. Magnetization of these MN was almost zero at room temperature in the absence of an applied magnetic field, indicating their superparamagnetic behavior. Magnetization was lower and the superparamagnetic fraction was higher for Fe3O4-OA-MN and Fe3O4-PEG-MN compared to Fe3O4-MN studied using a Mossbauer spectrometer. Compared to the control, an increased killing (35%) was observed in human breast cancer cells (MCF7) after Fe3O4-OA-MN treatment, which was further enhanced (65%) under induction heating conditions. However, MCF7 cells treated with Fe3O4-MN or Fe3O4-PEG-MN showed 5–10% killing after induction heating. These results showed the characterization of MN with different lipophilicity and suggests their suitability for hyperthermia applications in cancer therapy.

297 citations

Journal ArticleDOI
TL;DR: The efficacy of MN-OA in killing of tumor cells by cellular hyperthermia is suggested and a new approach to achieve dispersion of OA functionalized MN (MN-OA) in aqueous medium using sodium carbonate is employed, which improves their biological applicability.

130 citations

Journal ArticleDOI
TL;DR: The results suggest that Triphala possessed ability to induce cytotoxicity in tumor cells but spared the normal cells, and the substantial regression of transplanted tumor in mice fed withTriphala points to its potential use as an anticancer drug for clinical treatment.

129 citations

Journal ArticleDOI
01 Jan 2013-Cytokine
TL;DR: Comparisons and subtle differences in basal and radiation-induced cytokine profile of different tumor cell lines are revealed, and its influence on growth and survival of respective bystander cells may add a new dimension to the current understanding about role of cytokines in cancer biology.

110 citations

Journal ArticleDOI
TL;DR: In this article, the role of cellular redox and redox sensitive transcription factor, Nrf2 in the radiosensitivity of prostate cancer cell lines PC3 and DU145, has been investigated.

100 citations


Cited by
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Journal ArticleDOI
Geou Yarh Liou1, Peter Storz1
TL;DR: The generation of ROS within tumour cells, their detoxification, their cellular effects, as well as the major signalling cascades they utilize are discussed, but also an outlook on their modulation in therapeutics is provided.
Abstract: Elevated rates of reactive oxygen species (ROS) have been detected in almost all cancers, where they promote many aspects of tumour development and progression. However, tumour cells also express increased levels of antioxidant proteins to detoxify from ROS, suggesting that a delicate balance of intracellular ROS levels is required for cancer cell function. Further, the radical generated, the location of its generation, as well as the local concentration is important for the cellular functions of ROS in cancer. A challenge for novel therapeutic strategies will be the fine tuning of intracellular ROS signalling to effectively deprive cells from ROS-induced tumour promoting events, towards tipping the balance to ROS-induced apoptotic signalling. Alternatively, therapeutic antioxidants may prevent early events in tumour development, where ROS are important. However, to effectively target cancer cells specific ROS-sensing signalling pathways that mediate the diverse stress-regulated cellular functions need to be identified. This review discusses the generation of ROS within tumour cells, their detoxification, their cellular effects, as well as the major signalling cascades they utilize, but also provides an outlook on their modulation in therapeutics.

2,625 citations

Journal Article
TL;DR: Research data show that more resistant stem cells than common cancer cells exist in cancer patients, and to identify unrecognized differences between cancer stem cells and cancer cells might be able to develop effective classification, diagnose and treat for cancer.
Abstract: Stem cells are defined as cells able to both extensively self-renew and differentiate into progenitors. Research data show that more resistant stem cells than common cancer cells exist in cancer patients.To identify unrecognized differences between cancer stem cells and cancer cells might be able to develope effective classification,diagnose and treat ment for cancer.

2,194 citations

Journal ArticleDOI
TL;DR: This text is a general introduction to radiation biology and a complete, self-contained course especially for residents in diagnostic radiology and nuclear medicine that follows the Syllabus in Radiation Biology of the RSNA.
Abstract: The text consists of two sections, one for those studying or practicing diagnostic radiology, nuclear medicine and radiation oncology; the other for those engaged in the study or clinical practice of radiation oncology--a new chapter, on radiologic terrorism, is specifically for those in the radiation sciences who would manage exposed individuals in the event of a terrorist event. The 17 chapters in Section I represent a general introduction to radiation biology and a complete, self-contained course especially for residents in diagnostic radiology and nuclear medicine that follows the Syllabus in Radiation Biology of the RSNA. The 11 chapters in Section II address more in-depth topics in radiation oncology, such as cancer biology, retreatment after radiotherapy, chemotherapeutic agents and hyperthermia.

1,359 citations

Journal ArticleDOI
TL;DR: In this review, state-of-the-art studies concerning recent advances in nanotechnology-mediated multimodal synergistic therapy will be systematically discussed, with an emphasis on the construction of multifunctional nanomaterials for realizing bimodal and trimodal synergy therapy.
Abstract: The complexity, diversity, and heterogeneity of tumors seriously undermine the therapeutic potential of treatment. Therefore, the current trend in clinical research has gradually shifted from a focus on monotherapy to combination therapy for enhanced treatment efficacy. More importantly, the cooperative enhancement interactions between several types of monotherapy contribute to the naissance of multimodal synergistic therapy, which results in remarkable superadditive (namely “1 + 1 > 2”) effects, stronger than any single therapy or their theoretical combination. In this review, state-of-the-art studies concerning recent advances in nanotechnology-mediated multimodal synergistic therapy will be systematically discussed, with an emphasis on the construction of multifunctional nanomaterials for realizing bimodal and trimodal synergistic therapy as well as the intensive exploration of the underlying synergistic mechanisms for explaining the significant improvements in synergistic therapeutic outcome. Furtherm...

1,220 citations

Journal ArticleDOI
TL;DR: This review paper highlights the recent exciting developments in dual and multi-stimuli responsive polymeric nanoparticles for precision drug delivery applications, with a particular focus on their design, drug release performance, and therapeutic benefits.

1,098 citations