Author
Bakr F. Abdel-Wahab
Other affiliations: Shaqra University, Cairo University, King Saud University ...read more
Bio: Bakr F. Abdel-Wahab is an academic researcher from Mansoura University. The author has contributed to research in topics: Pyrazole & Ring (chemistry). The author has an hindex of 21, co-authored 137 publications receiving 1581 citations. Previous affiliations of Bakr F. Abdel-Wahab include Shaqra University & Cairo University.
Topics: Pyrazole, Ring (chemistry), Chemistry, Thiazole, Benzofuran
Papers
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TL;DR: 2-Acetylbenzofuran 1 on treatment with substituted aldehydes affords the corresponding chalcones 2a-c, and pyrazolines 7a-d were synthesized by treating 4a,b with phenacyl bromides in refluxing ethanol.
210 citations
TL;DR: The Groebke–Blackburn–Bienaymé reaction is used for the one-pot synthesis of therapeutically relevant fused imidazoles bridgehead nitrogen heterocyclic compounds from readily available aldehyde, isocyanide and amidine building blocks.
Abstract: The Groebke–Blackburn–Bienayme reaction (GBBR) is used for the one-pot synthesis of therapeutically relevant fused imidazoles bridgehead nitrogen heterocyclic compounds from readily available aldehyde, isocyanide and amidine building blocks. The reaction is driven by a wide range of catalysts and can be performed either under solvent or solvent-free conditions, or under microwave irradiation as heat source. The GBBR products can be used for the synthesis of a variety of more complex scaffolds via postmodification reactions. These include cyclization and nucleophilic substitution as well as further MCRs. The GBBR reaction has seen diverse applications in combinatorial and medicinal chemistry and its products are of great use in drug discovery. In this review, we summarize the efforts of the chemistry community in the progress and applications of GBBR since 1998. This review also includes some biological profiles and synthetic scopes of GBBR products. The component variations, postmodifications and secondary transformations will also be discussed throughout this review.
127 citations
TL;DR: 1-(5-methyl-2-phenyl-1H-imidazol-4-yl)ethanone 1 was prepared and used as a precursor for the synthesis of new thiazole, arylidiene and coumarin derivatives and proved to exhibit potent antioxidative activity as reflected in the ability to inhibit lipid per-oxidation in rat brain and kidney homogenates and rate erythrocyte hemolysis.
124 citations
TL;DR: The newly synthesized compounds 5a, 5c, 11b and 11c displayed excellent antimicrobial activity and their minimum inhibitory concentration (MIC) against most of test organisms was performed.
76 citations
TL;DR: In this paper, a review summarizes the synthetic methods, reactions and biological applications of 2- chloroquinoline-3-carbaldehydes during the period from 1999 to 2011.
Abstract: This review summarizes the synthetic methods, reactions and biological applications of 2- chloroquinoline-3-carbaldehydes during the period from 1999 to 2011. The reactions are subdivided in groups that cover reactions at the chloro or aldehyde substituent and reactions which involve both groups. Most reaction types have been successfully applied and used in the production of biological active compounds.
65 citations
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TL;DR: The present work aims to summarize the current approaches adopted for the synthesis of the 1,2,3-triazole and medicinal significance of these architectures as a lead structure for the discovery of drug molecules such as COX-1/COX-2 inhibitors, HIV protease inhibitors, CB1 cannabinoid receptor antagonist and much more which are in the pipeline of clinical trials.
563 citations
TL;DR: This work systematically gives a comprehensive review in current developments of imidazole‐based compounds in the whole range of medicinal chemistry as anticancer, antifungal, antibacterial, antitubercular, anti‐inflammatory, antineuropathic, antihypertensive, antihistaminic, antiparasitic, antiobesity, antiviral, and other medicinal agents, together with their potential applications in diagnostics and pathology.
Abstract: Imidazole ring is an important five-membered aromatic heterocycle widely present in natural products and synthetic molecules. The unique structural feature of imidazole ring with desirable electron-rich characteristic is beneficial for imidazole derivatives to readily bind with a variety of enzymes and receptors in biological systems through diverse weak interactions, thereby exhibiting broad bioactivities. The related research and developments of imidazole-based medicinal chemistry have become a rapidly developing and increasingly active topic. Particularly, numerous imidazole-based compounds as clinical drugs have been extensively used in the clinic to treat various types of diseases with high therapeutic potency, which have shown the enormous development value. This work systematically gives a comprehensive review in current developments of imidazole-based compounds in the whole range of medicinal chemistry as anticancer, antifungal, antibacterial, antitubercular, anti-inflammatory, antineuropathic, antihypertensive, antihistaminic, antiparasitic, antiobesity, antiviral, and other medicinal agents, together with their potential applications in diagnostics and pathology. It is hoped that this review will be helpful for new thoughts in the quest for rational designs of more active and less toxic imidazole-based medicinal drugs, as well as more effective diagnostic agents and pathologic probes.
558 citations
TL;DR: This critical review documents the development of organocatalytic indole alkylation strategies, until the end of 2009 (127 references).
Abstract: The desire for new synthetic methodologies for the rapid construction of enantiomerically pure substituted indole has been a fruitful driving force for chemical research in the last few years. This research line has produced a stunning array of enantioselective technologies either metal or organocatalyzed. This critical review documents the development of organocatalytic indole alkylation strategies, until the end of 2009 (127 references).
418 citations
TL;DR: The present review is endeavour to highlight the progress in the various pharmacological activities of benzofuran derivatives in the current literature with an update of recent research findings on this nucleus.
363 citations