Balram Soni

Bio: Balram Soni is an academic researcher from Jodhpur National University. The author has contributed to research in topics: Benzimidazole & Quantitative structure–activity relationship. The author has an hindex of 3, co-authored 8 publications receiving 99 citations.

Extraction and Isolation of Marmelosin from Aegle Marmelos, Synthesis and Evaluation of Their Derivative as Antidiabetic Agent

Abstract: Diabetes is one of the major health problems, the world is facing today. It is rising in an alarming rate necessitating alternative treatment methods. The present study has been undertaken to evaluate the anti-diabetic activity of marmelosin extracted from Aegle marmelos. The extraction of plant material in different solvent like petroleum ether, chloroform and ethanol by soxhelation was carried out. Marmelosin was separated out from extraction of Aegle marmelos by Column chromatography methods. Marmelosin derivatives were synthesized using Nitration, Sulphonation and Bromination reaction. The synthesized compounds were evaluated for anti-diabetic activitiy. The effect of marmelosin and its derivatives on hyperglycemia induced with alloxan on repeated administration was studied on male wistar rat. The estimation of blood sugar was carried out by the method GOD-PAP enzymatic method. The results were satisfactory, as significant decrease in the blood glucose levels after repeated administration was observed.

QSAR modeling of benzoxazole derivatives as antimicrobial agents

Abstract: A quantitative structure activity relationship study on a series of 5 (or 6)-nitro/amino-2- (substituted phenyl/benzyl)-benzoxazole analogues were made using combination of various thermodynamic, electronic and spatial descriptors. Several statistical expressions were developed using stepwise multiple liner regression analysis. The best model was validated by leave-one-out method of cross-validation. The study revealed that the thermodynamic property, i.e., Standard Gibbs free energy contributed positively, Electronic property like Electronic energy contributed positively and HOMO energy and Repulsion energy contributed negatively. The study suggested that substitution of group at R1 position on benzoxazole ring with electron withdrawing group favourable for the antibacterial activity. The quantitative structure activity relationship study provides important structural insights in designing of potent antibacterial agents.

DEVELOPMENT AND VALIDATION OF LORNOXICAM BY SECOND ORDER DERIVATIVE SPECTROSCOPY Research Article

Abstract: Simple, precise and cost effective second order derivative spectrophotometric method has been developed for the estimation of Lornoxicam in bulk and its pharmaceutical formulations. Lornoxicam shows λ max at 257.2 nm in second order derivative spectrum. The drug follows Beer-Lambert's law in the concentration range of 7.5 - 25.0 μg/ml with correlation coefficient of 0.999. The method was validated by following analytical performance parameters suggested by the International Conference on Harmonization. All validation parameters were within the acceptable range. The developed method was successfully applied to estimate the amount of Lornoxicam in bulk and pharmaceutical dosage form.

Phytochemical evaluation, antimicrobial activity, and determination of bioactive components from leaves of Aegle marmelos.

Abstract: The therapeutic value of Aegle marmelos Correa (Rutaceae), commonly known as ''Bael," has been recognized as a component of traditional medication for the treatment of various human ailments. The plant, though, being highly explored, still lacks sufficient evidences for the best variety possessing the highest degree of medicinal values. The present study is focused on phytochemical screening of aqueous and methanolic leaf extracts of 18 varieties/accessions of A. marmelos. The crude extracts of A. marmelos revealed the presence of several biologically active phytochemicals with the highest quantity of alkaloids, flavonoids, and phenols in Pant Aparna variety. The antibacterial efficacy was investigated against pathogenic bacterial strains and the highest inhibitory activity of aqueous extract was obtained against S. epidermidis, whereas methanolic extract was found to be most potent against S. aureus at 40 mg/mL concentration. However, in aqueous : ethanol, the best results were observed against E. aerogenes followed by K. pneumonia and S. epidermidis. The MIC of aqueous and methanol extract of Aegle marmelos ranged from 10 mg/mL to 40 mg/mL whereas in aqueous : ethanol it ranged between 40 mg/mL and 160 mg/mL. The GC-MS analysis revealed the presence of many bioactive compounds such as flavonoids, alcohols, aldehydes, aromatic compounds, fatty acid methyl esters, terpenoids, phenolics, and steroids that can be postulated for antibacterial activity.

Medicinal significance of benzothiazole scaffold: an insight view

Abstract: Heterocycles bearing nitrogen, sulphur and thiazole moieties constitute the core structure of a number of biologically interesting compounds. Benzothiazole, a group of xenobiotic compounds containing a benzene ring fused with a thiazole ring, are used worldwide for a variety of therapeutic applications. Benzothiazole and their heterocyclic derivatives represent an important class of compounds possessing a wide spectrum of biological activities. The myriad spectrum of medicinal properties associated with benzothiazole related drugs has encouraged the medicinal chemists to synthesize a large number of novel therapeutic agents. Several analogues containing benzothiazole ring system exhibit significant antitumour, antimicrobial, antidiabetic, anti-inflammatory, anticonvulsant, antiviral, antioxidant, antitubercular, antimalarial, antiasthmatic, anthelmintic, photosensitizing, diuretic, analgesic and other activities. This article is an attempt to present the research work reported in recent scientific literat...

Dendrimers as Pharmaceutical Excipients: Synthesis, Properties, Toxicity and Biomedical Applications.

Abstract: The European Medicines Agency (EMA) and the Current Good Manufacturing Practices (cGMP) in the United States of America, define excipient as the constituents of the pharmaceutical form other than the active ingredient, i.e., any component that is intended to furnish pharmacological activity. Although dendrimers do not have a pharmacopoeia monograph and, therefore, cannot be recognized as a pharmaceutical excipient, these nanostructures have received enormous attention from researchers. Due to their unique properties, like the nanoscale uniform size, a high degree of branching, polyvalency, aqueous solubility, internal cavities, and biocompatibility, dendrimers are ideal as active excipients, enhancing the solubility of poorly water-soluble drugs. The fact that the dendrimer's properties are controllable during their synthesis render them promising agents for drug-delivery applications in several pharmaceutical formulations. Additionally, dendrimers can be used for reducing the drug toxicity and for the enhancement of the drug efficacy. This review aims to discuss the properties that turn dendrimers into pharmaceutical excipients and their potential applications in the pharmaceutical and biomedical fields.